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  • Schmauck-Medina, TomasAkershus University Hospital (author)

New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-08-29
  • Impact Journals, LLC,2022
  • 11 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:6ebb2310-6dc7-40c4-bd2a-5abfc5c2b0ba
  • https://lup.lub.lu.se/record/6ebb2310-6dc7-40c4-bd2a-5abfc5c2b0baURI
  • https://doi.org/10.18632/aging.204248DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Molière, AdrianAkershus University Hospital (author)
  • Lautrup, SofieAkershus University Hospital (author)
  • Zhang, JianyingAkershus University Hospital (author)
  • Chlopicki, StefanJagiellonian University (author)
  • Madsen, Helena BorlandUniversity of Copenhagen (author)
  • Cao, ShuqinAkershus University Hospital (author)
  • Soendenbroe, CasperBispebjerg Hospital (author)
  • Mansell, ElsLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,University College London,UCL Cancer Institute(Swepub:lu)so6020ma (author)
  • Vestergaard, Mark BitschCopenhagen University Hospital (author)
  • Li, ZhiquanUniversity of Copenhagen (author)
  • Shiloh, YosefTel-Aviv University (author)
  • Opresko, Patricia L.University of Pittsburgh (author)
  • Egly, Jean MarcUniversity of Strasbourg (author)
  • Kirkwood, ThomasUniversity of Newcastle upon Tyne,University of Copenhagen (author)
  • Verdin, EricBuck Institute for Research on Aging (author)
  • Bohr, Vilhelm A.University of Copenhagen,National Institute on Aging, United States (author)
  • Cox, Lynne S.University of Oxford (author)
  • Stevnsner, TinnaAarhus University (author)
  • Rasmussen, Lene JuelUniversity of Copenhagen (author)
  • Fang, Evandro F.Akershus University Hospital (author)
  • Akershus University HospitalJagiellonian University (creator_code:org_t)

Related titles

  • In:Aging: Impact Journals, LLC14:16, s. 6829-68391945-4589

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