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Relevance of biomar...
Relevance of biomarkers across different neurodegenerative
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- Ehrenberg, Alexander J. (author)
- University of California, Berkeley,University of California, San Francisco
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- Khatun, Ayesha (author)
- University College London
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- Coomans, Emma (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Betts, Matthew J. (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Otto von Guericke University Magdeburg
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- Capraro, Federica (author)
- Francis Crick Institute
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- Thijssen, Elisabeth H. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,University of California, San Francisco
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- Senkevich, Konstantin (author)
- Petersburg Nuclear Physics Institute (PNPI),Pavlov University
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- Bharucha, Tehmina (author)
- University of Oxford
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- Jafarpour, Mehrsa (author)
- University College London
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- Young, Peter N.E. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Jagust, William (author)
- University of California, Berkeley,Lawrence Berkeley National Laboratory
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- Carter, Stephen F. (author)
- University of Manchester,University of Cambridge
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- Lashley, Tammaryn (author)
- University College London
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- Grinberg, Lea T. (author)
- University of São Paulo,University of California, San Francisco
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- Pereira, Joana B. (author)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Mattsson-Carlgren, Niklas (author)
- Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Sahlgrenska Academy,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Hanrieder, Jörg, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Schöll, Michael (author)
- Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Sahlgrenska Academy,University College London,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Paterson, Ross W. (author)
- University College London
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(creator_code:org_t)
- 2020-05-13
- 2020
- English.
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In: Alzheimer's Research and Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 12
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Abstract
Subject headings
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- Background: The panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and increasing use, appropriate implementation and interpretation are paramount. Various biomarkers feature nuanced differences in strengths, limitations, and biases that must be considered when investigating disease etiology and clinical utility. For example, neuropathological investigations of Alzheimer's disease pathogenesis can fall in disagreement with conclusions reached by biomarker-based investigations. Considering the varied strengths, limitations, and biases of different research methodologies and approaches may help harmonize disciplines within the neurodegenerative disease field. Purpose of review: Along with separate review articles covering fluid and imaging biomarkers in this issue of Alzheimer's Research and Therapy, we present the result of a discussion from the 2019 Biomarkers in Neurodegenerative Diseases course at the University College London. Here, we discuss themes of biomarker use in neurodegenerative disease research, commenting on appropriate use, interpretation, and considerations for implementation across different neurodegenerative diseases. We also draw attention to areas where biomarker use can be combined with other disciplines to understand issues of pathophysiology and etiology underlying dementia. Lastly, we highlight novel modalities that have been proposed in the landscape of neurodegenerative disease research and care.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Amyloid
- Biomarkers
- Cerebrospinal fluid
- Magnetic resonance imaging
- Neurodegenerative diseases
- Neurofilament light chain
- Plasma biomarkers
- Positron emission tomography
- Tau
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Ehrenberg, Alexa ...
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Khatun, Ayesha
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Coomans, Emma
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Betts, Matthew J ...
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Capraro, Federic ...
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Thijssen, Elisab ...
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Senkevich, Konst ...
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Bharucha, Tehmin ...
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Jafarpour, Mehrs ...
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Young, Peter N.E ...
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Jagust, William
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Carter, Stephen ...
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Lashley, Tammary ...
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Grinberg, Lea T.
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Pereira, Joana B ...
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Mattsson-Carlgre ...
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Ashton, Nicholas ...
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Hanrieder, Jörg, ...
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Zetterberg, Henr ...
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Schöll, Michael
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Paterson, Ross W ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Neurology
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomedical Labor ...
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MEDICAL AND HEAL ...
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and Neurosciences
- Articles in the publication
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Alzheimer's Rese ...
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Lund University
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Karolinska Institutet
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University of Gothenburg