Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort

Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.

Gladman, D (author)
Ibanez, D (author)
Fortin, P (author)
Sanchez-Guerrero, J (author)
Bae, S (author)
Clarke, A (author)
Bernatsky, S (author)
Gordon, C (author)
Hanly, J (author)
Wallace, D (author)
Isenberg, D (author)
Ginzler, E (author)
Merrill, J (author)
Alarcon, G (author)
Steinsson, K (author)
Petri, M (author)
Dooley, M A (author)
Bruce, I (author)
Manzi, S (author)
Khamashta, M (author)
Ramsey-Goldman, R (author)
Zoma, A (author)
Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-gst (author)
Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni (author)
Maddison, P (author)
Font, J (author)
van Vollenhoven, RKarolinska Institutet (author)
Aranow, C (author)
Kalunian, K (author)
Stoll, T (author)
Buyon, J (author)
Reumatologi och molekylär skelettbiologiSektion III (creator_code:org_t)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

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