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Search: onr:"swepub:oai:lup.lub.lu.se:6fbb2a47-e96e-4aa3-b61f-f330c7d04464" > Sex differences in ...

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  • Wood, Madeline E.University of Toronto,Sunnybrook Health Sciences Centre (author)

Sex differences in associations between APOE ε2 and longitudinal cognitive decline

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-03-30
  • Wiley,2023

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:6fbb2a47-e96e-4aa3-b61f-f330c7d04464
  • https://lup.lub.lu.se/record/6fbb2a47-e96e-4aa3-b61f-f330c7d04464URI
  • https://doi.org/10.1002/alz.13036DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • INTRODUCTION: We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples. METHODS: We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately. RESULTS: In both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE ε3/ε3 carriers, cognitive trajectories did not differ between sexes. There were no sex-specific associations of APOE ε2 with cognition in NHB participants (N = 2010). DISCUSSION: In NHW adults, APOE ε2 may protect men but not women against cognitive decline. Highlights: We studied sex-specific apolipoprotein E (APOE) ε2 effects on cognitive decline. In non-Hispanic White (NHW) adults, APOE ε2 selectively protects men against decline. Among men, APOE ε2 was more protective than APOE ε3/ε3. In women, APOE ε2 was no more protective than APOE ε3/ε3. Among APOE ε2 carriers, men had slower decline than women. There were no sex-specific APOE ε2 effects in non-Hispanic Black (NHB) adults.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Xiong, Lisa Y.University of Toronto,Sunnybrook Health Sciences Centre (author)
  • Wong, Yuen YanUniversity of Toronto,Sunnybrook Health Sciences Centre (author)
  • Buckley, Rachel F.Melbourne School of Psychological Sciences,Harvard Medical School,University of Melbourne (author)
  • Swardfager, WalterSunnybrook Health Sciences Centre,University of Toronto (author)
  • Masellis, MarioSunnybrook Health Sciences Centre,University of Toronto (author)
  • Lim, Andrew S.P.University of Toronto,Sunnybrook Health Sciences Centre (author)
  • Nichols, EmmaJohns Hopkins Bloomberg School of Public Health (author)
  • Joie, Renaud LaUniversity of California, San Francisco (author)
  • Casaletto, Kaitlin B.University of California, San Francisco (author)
  • Kumar, Raj G.Icahn School of Medicine at Mount Sinai (author)
  • Dams-O'Connor, KristenIcahn School of Medicine at Mount Sinai (author)
  • Palta, PriyaColumbia University (author)
  • George, Kristen M.University of California, Davis (author)
  • Satizabal, Claudia L.Boston University,University of Texas Health Science Centre (author)
  • Barnes, Lisa L.Rush Alzheimer's Disease Center (author)
  • Schneider, Julie A.Rush Alzheimer's Disease Center (author)
  • Binet, Alexa PichetteLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)al1314pi (author)
  • Villeneuve, SylviaMcConnell Brain Imaging Centre,McGill University (author)
  • Pa, JudyUniversity of Southern California (author)
  • Brickman, Adam M.Columbia University (author)
  • Black, Sandra E.Sunnybrook Health Sciences Centre,University of Toronto (author)
  • Rabin, Jennifer S.University of Toronto,Sunnybrook Health Sciences Centre (author)
  • University of TorontoSunnybrook Health Sciences Centre (creator_code:org_t)
  • ADNI and Prevent-AD Research Groups

Related titles

  • In:Alzheimer's and Dementia: Wiley19:10, s. 4651-46611552-52601552-5279

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