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Differential expres...
Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X
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- Haraldsson, Stefan (author)
- Copenhagen University Hospital
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- Klarskov, Louise (author)
- Gentofte Hospital
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- Nilbert, Mef (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Copenhagen University Hospital
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- Bernstein, Inge (author)
- Aalborg University,Copenhagen University Hospital
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- Bonde, Jesper (author)
- Copenhagen University Hospital
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- Holck, Susanne (author)
- Copenhagen University Hospital
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(creator_code:org_t)
- 2017-08-17
- 2017
- English.
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In: BMC Clinical Pathology. - : Springer Science and Business Media LLC. - 1472-6890. ; 17:1
- Related links:
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Abstract
Subject headings
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- Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p < 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, < 0.01, and < 0.001, respectively). We observed no differences in the expression patterns of CK7 and CDX2. Conclusions: In summary, we identified significant differences in the immunoprofiles of colorectal cancers linked to FCCTX and Lynch syndrome with a more sporadic-like profile in the former group and a more distinct profile with frequent MUC6 positivity in the latter group.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Fcctx
- Hereditary non-polyposis colorectal cancer
- Immunohistochemical profile
- Lynch syndrome
Publication and Content Type
- art (subject category)
- ref (subject category)
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