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Effects of the DICE...
Effects of the DICE Method to Improve Timely Recognition and Treatment of Neuropsychiatric Symptoms in Early Alzheimer's Disease at the Memory Clinic : The BEAT-IT Study
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- Eikelboom, Willem S. (author)
- Erasmus University Medical Center
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- Van Den Berg, Esther (author)
- Erasmus University Medical Center
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- Coesmans, Michiel (author)
- Erasmus University Medical Center
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- Goudzwaard, Jeannette A. (author)
- Erasmus University Medical Center
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- Koopmanschap, Marc (author)
- Erasmus University Rotterdam
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- Lazaar, Najoua (author)
- Erasmus University Medical Center
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- Van Bruchem-Visser, Rozemarijn L. (author)
- Erasmus University Medical Center
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- Driesen, Jan J.M. (author)
- Franciscus Gasthuis & Vlietland
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- Den Heijer, Tom (author)
- Franciscus Gasthuis & Vlietland
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- Hoogers, Susanne (author)
- Spijkenisse Medical Center
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- De Jong, Frank Jan (author)
- Erasmus University Medical Center
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- Mattace-Raso, Francesco U. S. (author)
- Erasmus University Medical Center
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- Thomeer, Elsbeth C. (author)
- Maasstad Ziekenhuis
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- Vrenken, Suzanne (author)
- Spijkenisse Medical Center
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- Vroegindeweij, Lilian J.H.M. (author)
- Van Weel-Bethesda Hospital
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- Zuidema, Sytse U. (author)
- University Medical Center Groningen
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- Singleton, Ellen H. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Van Swieten, John C. (author)
- Erasmus University Medical Center
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Papma, Janne M. (author)
- Erasmus University Medical Center
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(creator_code:org_t)
- 2023
- 2023
- English 17 s.
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In: Journal of Alzheimer's Disease. - 1387-2877. ; 93:4, s. 1407-1423
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Abstract
Subject headings
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- Background: Neuropsychiatric symptoms (NPS) are highly prevalent in Alzheimer's disease (AD) and are associated with negative outcomes. However, NPS are currently underrecognized at the memory clinic and non-pharmacological interventions are scarcely implemented. Objective: To evaluate the effectiveness of the Describe, Investigate, Create, Evaluate (DICE) method™ to improve the care for NPS in AD at the memory clinic. Methods: We enrolled sixty community-dwelling people with mild cognitive impairment or AD dementia and NPS across six Dutch memory clinics with their caregivers. The first wave underwent care as usual (n = 36) and the second wave underwent the DICE method (n = 24). Outcomes were quality of life (QoL), caregiver burden, NPS severity, NPS-related distress, competence managing NPS, and psychotropic drug use. Reliable change index was calculated to identify responders to the intervention. A cost-effectiveness analysis was performed and semi-structured interviews with a subsample of the intervention group (n = 12). Results: The DICE method did not improve any outcomes over time compared to care as usual. Half of the participants of the intervention group (52%) were identified as responders and showed more NPS and NPS-related distress at baseline compared to non-responders. Interviews revealed substantial heterogeneity among participants regarding NPS-related distress, caregiver burden, and availability of social support. The intervention did not lead to significant gains in quality-adjusted life years and well-being years nor clear savings in health care and societal costs. Conclusion: The DICE method showed no benefits at group-level, but individuals with high levels of NPS and NPS-related distress may benefit from this intervention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- Alzheimer's disease
- apathy
- behavioral and psychological symptoms of dementia
- delivery of care
- dementia
- depression
- neuropsychiatric inventory
- neuropsychiatric symptoms
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Eikelboom, Wille ...
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Van Den Berg, Es ...
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Coesmans, Michie ...
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Goudzwaard, Jean ...
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Koopmanschap, Ma ...
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Lazaar, Najoua
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Van Bruchem-Viss ...
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Driesen, Jan J.M ...
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Den Heijer, Tom
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Hoogers, Susanne
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De Jong, Frank J ...
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Mattace-Raso, Fr ...
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Thomeer, Elsbeth ...
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Vrenken, Suzanne
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Vroegindeweij, L ...
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Zuidema, Sytse U ...
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Singleton, Ellen ...
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Van Swieten, Joh ...
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Ossenkoppele, Ri ...
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Papma, Janne M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
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Journal of Alzhe ...
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Lund University