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Longitudinal Tau PE...
Longitudinal Tau PET Using 18F-Flortaucipir : The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters
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- Visser, Denise (author)
- Vrije Universiteit Amsterdam
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- Tuncel, Hayel (author)
- Vrije Universiteit Amsterdam
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam
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- Yaqub, Maqsood (author)
- Vrije Universiteit Amsterdam
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- Wolters, Emma E. (author)
- Vrije Universiteit Amsterdam
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- Timmers, Tessa (author)
- Vrije Universiteit Amsterdam
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- Weltings, Emma (author)
- Vrije Universiteit Amsterdam
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- Coomans, Emma M. (author)
- Vrije Universiteit Amsterdam
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- den Hollander, Marijke E. (author)
- Vrije Universiteit Amsterdam
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- van der Flier, Wiesje M. (author)
- Vrije Universiteit Amsterdam
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- van Berckel, Bart N.M. (author)
- Vrije Universiteit Amsterdam
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- Golla, Sandeep S.V. (author)
- Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2022-10-20
- 2023
- English 6 s.
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In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505. ; 64:2, s. 281-286
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Abstract
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- Semiquantitative PET measures such as SUV ratio (SUVr) have several advantages over quantitative measures, such as practical applicability and relative computational simplicity. However, SUVr may potentially be affected by changes in blood flow, whereas quantitative measures such as nondisplaceable binding potential (BPND) are not. For 18F-flortaucipir PET, the sensitivity of SUVr for changes in blood flow is currently unknown. Therefore, we compared semiquantitative (SUVr) and quantitative (BPND) parameters of longitudinal 18F-flortaucipir PET scans and assessed their vulnerability to changes in blood flow. Methods: Subjects with subjective cognitive decline (n = 38) and Alzheimer disease patients (n = 24) underwent baseline and 2-y follow-up dynamic 18F-flortaucipir PET scans. BPND and relative tracer delivery were estimated using receptor parametric mapping, and SUVr at 80-100 min was calculated. Regional SUVrs were compared with corresponding distribution volume ratio (BPND + 1) using paired t tests. Additionally, simulations were performed to model effects of larger flow changes in different binding categories. Results: Results in subjective cognitive decline and Alzheimer disease showed only minor differences between SUVr and BPND changes over time. Relative tracer delivery changes were small in all groups. Simulations illustrated a variable bias for SUVr depending on the amount of binding. Conclusion: SUVr provided an accurate estimate of changes in specific binding for 18F-flortaucipir over a 2-y follow-up during which changes in flow were small. Notwithstanding, simulations showed that large(r) flow changes may affect 18F-flortaucipir SUVr. Given that it is currently unknown to what order of magnitude pharmacotherapeutic interventions may induce changes in cerebral blood flow, caution may be warranted when changes in flow are potentially large(r), as in clinical trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer disease
- dynamic (DVR/BPND)
- longitudinal 18F-flortaucipir PET
- quantification
- static (SUVr)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Visser, Denise
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Tuncel, Hayel
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Ossenkoppele, Ri ...
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Yaqub, Maqsood
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Wolters, Emma E.
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Timmers, Tessa
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Weltings, Emma
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Coomans, Emma M.
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den Hollander, M ...
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van der Flier, W ...
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van Berckel, Bar ...
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Golla, Sandeep S ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of nucle ...
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Journal of Nucle ...
- By the university
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Lund University