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Frataxin deficiency...
Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass
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Ristow, M (author)
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- Mulder, Hindrik (author)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
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Pomplun, D (author)
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Schulz, T (author)
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Muller-Schmehl, K (author)
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Krause, A (author)
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- Fex, Malin (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Puccio, H (author)
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Muller, J (author)
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Isken, F (author)
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Spranger, J (author)
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Muller-Wieland, D (author)
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Magnuson, MA (author)
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Mohlig, M (author)
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Koenig, M (author)
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Pfeiffer, AFH (author)
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: Journal of Clinical Investigation. - 0021-9738. ; 112:4, s. 527-534
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Abstract
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- Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing beta cells. We have disrupted expression of the mitochondrial protein frataxin selectively in pancreatic beta cells. Mice were born healthy but subsequently developed impaired glucose tolerance progressing to overt diabetes mellitus. These observations were explained by impairment of insulin secretion due to a loss of beta cell mass in knockout animals. This phenotype was preceded by elevated levels of reactive oxygen species in knockout islets, an increased frequency of apoptosis, and a decreased number of proliferating beta cells. Hence, disruption of the frataxin gene in pancreatic beta cells causes diabetes following cellular growth arrest and apoptosis, paralleled by an increase in reactive oxygen species in islets. These observations might provide insight into the deterioration of beta cell function observed in different subtypes of diabetes in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Ristow, M
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Mulder, Hindrik
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Pomplun, D
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Schulz, T
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Muller-Schmehl, ...
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Krause, A
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show more...
-
Fex, Malin
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Puccio, H
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Muller, J
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Isken, F
-
Spranger, J
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Muller-Wieland, ...
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Magnuson, MA
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Mohlig, M
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Koenig, M
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Pfeiffer, AFH
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Journal of Clini ...
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Lund University