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Increased Sensitivi...
Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.
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- Borggren, Marie (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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Repits, Johanna (author)
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Sterjovski, Jasminka (author)
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- Uchtenhagen, Hannes (author)
- Karolinska Institutet
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Churchill, Melissa J (author)
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Karlsson, Anders (author)
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- Albert, Jan (author)
- Karolinska Institutet
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- Achour, Adnane (author)
- Karolinska Institutet
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Gorry, Paul R (author)
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- Fenyö, Eva Maria (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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- Jansson, Marianne (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- 2011-06-16
- 2011
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:6
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Abstract
Subject headings
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- Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Borggren, Marie
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Repits, Johanna
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Sterjovski, Jasm ...
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Uchtenhagen, Han ...
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Churchill, Melis ...
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Karlsson, Anders
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show more...
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Albert, Jan
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Achour, Adnane
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Gorry, Paul R
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Fenyö, Eva Maria
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Jansson, Mariann ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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PLoS ONE
- By the university
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Lund University
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Karolinska Institutet