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Glycemic index, gly...
Glycemic index, glycemic load, and risk of coronary heart disease : a pan-European cohort study
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- Sieri, Sabina (author)
- Istituto Nazionale dei Tumori,University of Cambridge
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- Agnoli, Claudia (author)
- Istituto Nazionale dei Tumori
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- Grioni, Sara (author)
- Istituto Nazionale dei Tumori
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization
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- Mattiello, Amalia (author)
- University of Naples Federico II,National Institute for Public Health and the Environment (RIVM)
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- Sluijs, Ivonne (author)
- University Medical Center Utrecht
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- Sanchez, Maria Jose (author)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Jakobsen, Marianne Uhre (author)
- Technical University of Denmark
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- Sweeting, Michael (author)
- University of Leicester,University of Cambridge
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- van der Schouw, Yvonne T. (author)
- University Medical Center Utrecht
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- Nilsson, Lena Maria, 1965- (author)
- Umeå universitet,Umeå University,Avdelningen för hållbar hälsa
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- Wennberg, Patrik, 1972- (author)
- Umeå universitet,Umeå University,Allmänmedicin
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- Katzke, Verena A. (author)
- German Cancer Research Centre
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- Kühn, Tilman (author)
- German Cancer Research Centre
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- Overvad, Kim (author)
- Aarhus University
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- Tong, Tammy Y.N. (author)
- University of Oxford
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- Conchi, Moreno Iribas (author)
- Health Research Institute of Navarra (IDISNA)
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- Quirós, José Ramón (author)
- Public Health Directorate
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García-Torrecillas, Juan Manuel (author)
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- Mokoroa, Olatz (author)
- Biodonostia Health Research Institute
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- Gómez, Jesús Humberto (author)
- Murcia Regional Health Council
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- Tjønneland, Anne (author)
- University of Copenhagen,Danish Cancer Society
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- Sonestedt, Emiliy (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Trichopoulou, Antonia (author)
- Hellenic Health Foundation, Athens
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- Karakatsani, Anna (author)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Valanou, Elissavet (author)
- Hellenic Health Foundation, Athens
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- Boer, Jolanda M.A. (author)
- National Institute for Public Health and the Environment (RIVM)
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- Verschuren, W. M.Monique (author)
- National Institute for Public Health and the Environment (RIVM)
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- Boutron-Ruault, Marie Christine (author)
- Stabilite genetique et oncogenese,Centre for Research in Epidemiology and Population Health (CESP)
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- Fagherazzi, Guy (author)
- Centre for Research in Epidemiology and Population Health (CESP),Stabilite genetique et oncogenese
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- Madika, Anne Laure (author)
- Centre for Research in Epidemiology and Population Health (CESP),University of Lille,Stabilite genetique et oncogenese
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- Bergmann, Manuela M. (author)
- German Institute of Human Nutrition
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- Schulze, Matthias B. (author)
- German Institute of Human Nutrition,University of Potsdam,German Centre for Cardiovascular Research
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- Ferrari, Pietro (author)
- International Agency for Research on Cancer, World Health Organization
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- Freisling, Heinz (author)
- International Agency for Research on Cancer, World Health Organization
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- Lennon, Hannah (author)
- International Agency for Research on Cancer, World Health Organization
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- Sacerdote, Carlotta (author)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Masala, Giovanna (author)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Tumino, Rosario (author)
- Civic and M.P Arezzo Hospital
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- Riboli, Elio (author)
- Imperial College London
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- Wareham, Nicholas J. (author)
- University of Cambridge
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- Danesh, John (author)
- University of Cambridge
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- Forouhi, Nita G. (author)
- University of Cambridge
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- Butterworth, Adam S. (author)
- University of Cambridge
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- Krogh, Vittorio (author)
- Istituto Nazionale dei Tumori
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English 13 s.
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In: The American journal of clinical nutrition. - : Elsevier BV. - 1938-3207 .- 0002-9165. ; 112:3, s. 631-643
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Abstract
Subject headings
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- BACKGROUND: High carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index (GI) and glycemic load (GL) are associated with increased CHD risk. OBJECTIVES: The aim of this study was to determine whether dietary GI, GL, and available carbohydrates are associated with CHD risk in both sexes. METHODS: This large prospective study-the European Prospective Investigation into Cancer and Nutrition-consisted of 338,325 participants who completed a dietary questionnaire. HRs with 95% CIs for a CHD event, in relation to intake of GI, GL, and carbohydrates, were estimated using covariate-adjusted Cox proportional hazard models. RESULTS: After 12.8 y (median), 6378 participants had experienced a CHD event. High GL was associated with greater CHD risk [HR 1.16 (95% CI: 1.02, 1.31) highest vs. lowest quintile, p-trend 0.035; HR 1.18 (95% CI: 1.07, 1.29) per 50 g/day of GL intake]. The association between GL and CHD risk was evident in subjects with BMI (in kg/m2) ≥25 [HR: 1.22 (95% CI: 1.11, 1.35) per 50 g/d] but not in those with BMI <25 [HR: 1.09 (95% CI: 0.98, 1.22) per 50 g/d) (P-interaction = 0.022). The GL-CHD association did not differ between men [HR: 1.19 (95% CI: 1.08, 1.30) per 50 g/d] and women [HR: 1.22 (95% CI: 1.07, 1.40) per 50 g/d] (test for interaction not significant). GI was associated with CHD risk only in the continuous model [HR: 1.04 (95% CI: 1.00, 1.08) per 5 units/d]. High available carbohydrate was associated with greater CHD risk [HR: 1.11 (95% CI: 1.03, 1.18) per 50 g/d]. High sugar intake was associated with greater CHD risk [HR: 1.09 (95% CI: 1.02, 1.17) per 50 g/d]. CONCLUSIONS: This large pan-European study provides robust additional support for the hypothesis that a diet that induces a high glucose response is associated with greater CHD risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- cohort study
- coronary heart disease
- EPIC study
- EPIC-CVD study
- glycemic index
- glycemic load
- glycemic index
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Sieri, Sabina
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Agnoli, Claudia
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Grioni, Sara
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Weiderpass, Elis ...
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Mattiello, Amali ...
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Sluijs, Ivonne
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show more...
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Sanchez, Maria J ...
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Jakobsen, Marian ...
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Sweeting, Michae ...
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van der Schouw, ...
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Nilsson, Lena Ma ...
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Wennberg, Patrik ...
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Katzke, Verena A ...
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Kühn, Tilman
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Overvad, Kim
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Tong, Tammy Y.N.
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Conchi, Moreno I ...
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Quirós, José Ram ...
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García-Torrecill ...
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Mokoroa, Olatz
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Gómez, Jesús Hum ...
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Tjønneland, Anne
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Sonestedt, Emili ...
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Trichopoulou, An ...
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Karakatsani, Ann ...
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Valanou, Elissav ...
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Boer, Jolanda M. ...
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Verschuren, W. M ...
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Boutron-Ruault, ...
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Fagherazzi, Guy
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Madika, Anne Lau ...
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Bergmann, Manuel ...
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Schulze, Matthia ...
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Ferrari, Pietro
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Freisling, Heinz
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Lennon, Hannah
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Sacerdote, Carlo ...
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Masala, Giovanna
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Tumino, Rosario
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Riboli, Elio
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Wareham, Nichola ...
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Danesh, John
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Forouhi, Nita G.
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Butterworth, Ada ...
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Krogh, Vittorio
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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The American jou ...
- By the university
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Lund University
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Umeå University