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DNA methylation cha...
DNA methylation changes associated with prenatal mercury exposure : A meta-analysis of prospective cohort studies from PACE consortium
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- Lozano, Manuel (author)
- University of Valencia
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- Yousefi, Paul (author)
- University of Bristol
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- Broberg, Karin (author)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
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- Soler-Blasco, Raquel (author)
- University of Valencia
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- Miyashita, Chihiro (author)
- Hokkaido University
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- Pesce, Giancarlo (author)
- University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)
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- Kim, Woo Jin (author)
- Kangwon National University
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- Rahman, Mohammad (author)
- Harvard Medical School,Harvard Pilgrim Health Care Institute
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- Bakulski, Kelly M. (author)
- University of Michigan
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- Haug, Line S. (author)
- Norwegian Institute of Public Health
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- Ikeda-Araki, Atsuko (author)
- Hokkaido University
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- Huel, Guy (author)
- Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
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- Park, Jaehyun (author)
- Seoul National University
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- Relton, Caroline (author)
- University of Bristol
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- Vrijheid, Martine (author)
- Pompeu Fabra University,Centre for Research in Environmental Epidemiology
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- Rifas-Shiman, Sheryl (author)
- Harvard Medical School,Harvard Pilgrim Health Care Institute
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- Oken, Emily (author)
- Harvard Medical School,Harvard Pilgrim Health Care Institute
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- Dou, John F. (author)
- University of Michigan
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- Kishi, Reiko (author)
- Hokkaido University
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- Gutzkow, Kristine B. (author)
- Norwegian Institute of Public Health
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- Annesi-Maesano, Isabella (author)
- University of Montpellier
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- Won, Sungho (author)
- Seoul National University
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- Hivert, Marie France (author)
- Massachusetts General Hospital
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- Fallin, M. Daniele (author)
- Johns Hopkins Bloomberg School of Public Health
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- Vafeiadi, Marina (author)
- University of Crete Medical School
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- Ballester, Ferran (author)
- University of Valencia
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- Bustamante, Mariona (author)
- Pompeu Fabra University,Centre for Research in Environmental Epidemiology
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- Llop, Sabrina (author)
- CIBER Epidemiology and Public Health (CIBERESP),University of Valencia
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 204
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https://doi.org/10.1...
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Abstract
Subject headings
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- Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (DNAm) by meta-analysis in up to seven independent studies (n = 1462) as well as persistence of those relationships in blood from 7 to 8 year-old children (n = 794). In cord blood, we found limited evidence of differential DNAm at cg24184221 in MED31 (β = 2.28 × 10−4, p-value = 5.87 × 10−5) in relation to prenatal MeHg exposure. In child blood, we identified differential DNAm at cg15288800 (β = 0.004, p-value = 4.97 × 10−5), also located in MED31. This repeated link to MED31, a gene involved in lipid metabolism and RNA Polymerase II transcription function, may suggest a DNAm perturbation related to MeHg exposure that persists into early childhood. Further, we found evidence for association between prenatal MeHg exposure and child blood DNAm levels at two additional CpGs: cg12204245 (β = 0.002, p-value = 4.81 × 10−7) in GRK1 and cg02212000 (β = −0.001, p-value = 8.13 × 10−7) in GGH. Prenatal MeHg exposure was associated with DNAm modifications that may influence health outcomes, such as cognitive or anthropometric development, in different populations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- ALSPAC
- DNA methylation
- HELIX study
- Mercury
- Methylmercury
- PACE
- Prenatal exposure
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Lozano, Manuel
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Yousefi, Paul
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Broberg, Karin
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Soler-Blasco, Ra ...
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Miyashita, Chihi ...
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Pesce, Giancarlo
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show more...
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Kim, Woo Jin
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Rahman, Mohammad
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Bakulski, Kelly ...
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Haug, Line S.
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Ikeda-Araki, Ats ...
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Huel, Guy
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Park, Jaehyun
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Relton, Caroline
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Vrijheid, Martin ...
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Rifas-Shiman, Sh ...
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Oken, Emily
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Dou, John F.
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Kishi, Reiko
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Gutzkow, Kristin ...
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Annesi-Maesano, ...
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Won, Sungho
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Hivert, Marie Fr ...
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Fallin, M. Danie ...
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Vafeiadi, Marina
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Ballester, Ferra ...
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Bustamante, Mari ...
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Llop, Sabrina
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Environmental Re ...
- By the university
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Lund University
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Karolinska Institutet