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Outcome parameters ...
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Kirchhof, Paulus
(author)
Outcome parameters for trials in atrial fibrillation: executive summary
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2007-10-17
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Oxford University Press (OUP),2007
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:72a201ad-6e5b-44d6-92a4-b03cf006b825
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https://lup.lub.lu.se/record/969169URI
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https://doi.org/10.1093/eurheartj/ehm358DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Atrial fibrillation (AF), the most common atrial arrhythmia, has a complex aetiology and causes relevant morbidity and mortality due to different mechanisms, including but not limited to stroke, heart failure, and tachy- or bradyarrhythmia. Current therapeutic options (rate control, rhythm control, antithrombotic therapy, 'upstream therapy') only prevent a part of this burden of disease. Several new treatment modalities are therefore under evaluation in controlled trials. Given the multifold clinical consequences of AF, trials in AF patients should assess the effect of therapy in each of the main outcome domains. This paper describes an expert consensus of required outcome parameters in seven relevant outcome domains, namely death, stroke, symptoms and quality of life, rhythm, left ventricular function, cost, and emerging outcome parameters. In addition to these 'requirements' for outcome assessment in AF trials, further, more detailed outcome parameters are described. In addition to a careful selection of a relevant primary outcome parameter, coverage of outcomes in all major domains of AF- related morbidity and mortality is desirable for any clinical trial in AF.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Auricchio, Angelo
(author)
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Bax, Jeroen
(author)
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Crijns, Harry
(author)
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Camm, John
(author)
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Diener, Hans-Christoph
(author)
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Goette, Andreas
(author)
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Hindricks, Gerd
(author)
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Hohnloser, Stefan
(author)
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Kappenberger, Lukas
(author)
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Kuck, Karl-Heinz
(author)
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Lip, Gregory Y. H.
(author)
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Olsson, BertilLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kard-bol
(author)
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Meinertz, Thomas
(author)
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Priori, Silvia
(author)
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Ravens, Ursula
(author)
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Steinbeck, Gerhard
(author)
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Svernhage, Elisabeth
(author)
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Tijssen, Jan
(author)
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Vincent, Alphons
(author)
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Breithardt, Guenter
(author)
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KardiologiSektion II
(creator_code:org_t)
Related titles
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In:European Heart Journal: Oxford University Press (OUP)28:22, s. 2803-28171522-96450195-668X
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Kirchhof, Paulus
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Auricchio, Angel ...
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Bax, Jeroen
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Crijns, Harry
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Camm, John
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Diener, Hans-Chr ...
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show more...
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Goette, Andreas
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Hindricks, Gerd
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Hohnloser, Stefa ...
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Kappenberger, Lu ...
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Kuck, Karl-Heinz
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Lip, Gregory Y. ...
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Olsson, Bertil
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Meinertz, Thomas
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Priori, Silvia
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Ravens, Ursula
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Steinbeck, Gerha ...
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Svernhage, Elisa ...
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Tijssen, Jan
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Vincent, Alphons
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Breithardt, Guen ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Cardiac and Card ...
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European Heart J ...
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Lund University