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Pericyte-derived fi...
Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
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- Dias, David O. (author)
- Karolinska Institutet,Karolinska Institute
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- Kalkitsas, Jannis (author)
- Karolinska Institute
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- Kelahmetoglu, Yildiz (author)
- Karolinska Institute
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- Estrada, Cynthia P. (author)
- Karolinska Institutet
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- Tatarishvili, Jemal (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Holl, Daniel (author)
- Karolinska Institutet,Karolinska Institute
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- Jansson, Linda (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Banitalebi, Shervin (author)
- University of Oslo
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- Amiry-Moghaddam, Mahmood (author)
- University of Oslo
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- Ernst, Aurélie (author)
- Karolinska Institute,German Cancer Research Centre
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- Huttner, Hagen B. (author)
- University Hospital Erlangen
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- Kokaia, Zaal (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Lindvall, Olle (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Brundin, Lou (author)
- Karolinska Institutet
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- Frisén, Jonas (author)
- Karolinska Institutet,Karolinska Institute
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- Göritz, Christian (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2021-09-17
- 2021
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Abstract
Subject headings
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- Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic tissue generation and distribution of stromal cells across different lesions in the brain and spinal cord has not been systematically investigated in mice and humans. Furthermore, it is unknown whether scar-forming stromal cells have the same origin throughout the central nervous system and in different types of lesions. In the current study, we compared fibrotic scarring in human pathological tissue and corresponding mouse models of penetrating and non-penetrating spinal cord injury, traumatic brain injury, ischemic stroke, multiple sclerosis and glioblastoma. We show that the extent and distribution of stromal cells are specific to the type of lesion and, in most cases, similar between mice and humans. Employing in vivo lineage tracing, we report that in all mouse models that develop fibrotic tissue, the primary source of scar-forming fibroblasts is a discrete subset of perivascular cells, termed type A pericytes. Perivascular cells with a type A pericyte marker profile also exist in the human brain and spinal cord. We uncover type A pericyte-derived fibrosis as a conserved mechanism that may be explored as a therapeutic target to improve recovery after central nervous system lesions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Dias, David O.
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Kalkitsas, Janni ...
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Kelahmetoglu, Yi ...
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Estrada, Cynthia ...
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Tatarishvili, Je ...
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Holl, Daniel
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show more...
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Jansson, Linda
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Banitalebi, Sher ...
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Amiry-Moghaddam, ...
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Ernst, Aurélie
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Huttner, Hagen B ...
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Kokaia, Zaal
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Lindvall, Olle
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Brundin, Lou
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Frisén, Jonas
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Göritz, Christia ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University
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Karolinska Institutet