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Preclinical Single ...
Preclinical Single Photon Emission Computed Tomography of Alpha Particle-Emitting Radium-223
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- Abou, Diane S. (author)
- Washington University in St. Louis
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- Rittenbach, Andrew (author)
- University of Southern California
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- Tomlinson, Ryan E. (author)
- Thomas Jefferson University
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- Finley, Paige A. (author)
- Johns Hopkins University School of Medicine
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- Tsui, Benjamin (author)
- Johns Hopkins University School of Medicine
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- Simons, Brian W. (author)
- Baylor College of Medicine
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- Jha, Abhinav K. (author)
- Washington University in St. Louis
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- Ulmert, David (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of California, Los Angeles
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- Riddle, Ryan C. (author)
- Johns Hopkins University School of Medicine
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- Thorek, Daniel L.J. (author)
- Washington University in St. Louis
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Washington University in St Louis University of Southern California (creator_code:org_t)
- Mary Ann Liebert Inc, 2020
- 2020
- English 10 s.
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In: Cancer Biotherapy and Radiopharmaceuticals. - : Mary Ann Liebert Inc. - 1084-9785 .- 1557-8852. ; 35:7, s. 520-529
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http://dx.doi.org/10... (free)
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https://www.ncbi.nlm...
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Abstract
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- Objective: Dose optimization and pharmacokinetic evaluation of α-particle emitting radium-223 dichloride (223RaCl2) by planar γ-camera or single photon emission computed tomography (SPECT) imaging are hampered by the low photon abundance and injected activities. In this study, we demonstrate SPECT of 223Ra using phantoms and small animal in vivo models. Methods: Line phantoms and mice bearing 223Ra were imaged using a dedicated small animal SPECT by detecting the low-energy photon emissions from 223Ra. Localization of the therapeutic agent was verified by whole-body and whole-limb autoradiography and its radiobiological effect confirmed by immunofluorescence. Results: A state-of-the-art commercial small animal SPECT system equipped with a highly sensitive collimator enables collection of sufficient counts for three-dimensional reconstruction at reasonable administered activities and acquisition times. Line sources of 223Ra in both air and in a water scattering phantom gave a line spread function with a full-width-at-half-maximum of 1.45 mm. Early and late-phase imaging of the pharmacokinetics of the radiopharmaceutical were captured. Uptake at sites of active bone remodeling was correlated with DNA damage from the α particle emissions. Conclusions: This work demonstrates the capability to noninvasively define the distribution of 223RaCl2, a recently approved α-particle-emitting radionuclide. This approach allows quantitative assessment of 223Ra distribution and may assist radiation-dose optimization strategies to improve therapeutic response and ultimately to enable personalized treatment planning.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- molecular imaging
- pharmacokinetics
- theranostics
- α-particle radiotherapy
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Abou, Diane S.
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Rittenbach, Andr ...
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Tomlinson, Ryan ...
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Finley, Paige A.
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Tsui, Benjamin
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Simons, Brian W.
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show more...
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Jha, Abhinav K.
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Ulmert, David
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Riddle, Ryan C.
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Thorek, Daniel L ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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Cancer Biotherap ...
- By the university
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Lund University