Familial risk of pleural mesothelioma increased drastically in certain occupations : A nationwide prospective cohort study

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Kharazmi, ElhamGerman Cancer Research Centre,National Centre of Tumor Diseases (author)

Familial risk of pleural mesothelioma increased drastically in certain occupations : A nationwide prospective cohort study

Article/chapterEnglish2018

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Elsevier BV,2018
6 s.

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LIBRIS-ID:oai:lup.lub.lu.se:75b9293d-200d-4e67-972c-4f78d32c275f
https://lup.lub.lu.se/record/75b9293d-200d-4e67-972c-4f78d32c275fURI
https://doi.org/10.1016/j.ejca.2018.07.139DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:139365568URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype

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Objective: We aimed to explore the effect of occupation on familial risk of pleural mesothelioma in a nationwide cohort study design. Method: The nationwide Swedish Family-Cancer Database includes all Swedes born after 1931 and their biological parents, totalling 16.1 million individuals with about 2.3 million cancer patients. Hazards ratios (HRs) were calculated adjusting for age, sex and region of residence. Results: Having asbestos-related occupation in the absence of family history of mesothelioma increased risk of mesothelioma more than threefold (adjusted HR = 3.2, 95% confidence interval [CI]: 3.0–3.5). In those who had a history of mesothelioma in their first-degree relatives and an asbestos-related occupation, risk of mesothelioma dramatically increased compared with individuals without such occupations and family history (without chronic obstructive pulmonary disease [COPD] HR = 24, 95% CI: 15–39; with COPD 45, 95% CI: 15–141). In those who had a family history of mesothelioma and no history of an asbestos-related occupation, risk of mesothelioma did not show significant increase compared with those who had no family history of mesothelioma and no asbestos-related occupation (HR = 1.6; 95% CI: 0.7–3.8). Conclusion: First-degree relatives of patients with pleural mesothelioma had a drastic risk of developing this malignancy in case of certain occupations, which shows a gene–environment interaction is probable in risk of mesothelioma.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
Familial risk
First-degree relatives
Mesothelioma
Occupation

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Chen, TianhuiZhejiang Academy of Medical Sciences(Swepub:lu)med-tce (author)
Fallah, MahdiNational Centre of Tumor Diseases,German Cancer Research Centre(Swepub:lu)med-mdf (author)
Sundquist, KristinaLund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Shimane University,Icahn School of Medicine at Mount Sinai(Swepub:lu)med-ksq (author)
Sundquist, JanLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Icahn School of Medicine at Mount Sinai,Shimane University(Swepub:lu)med-jsu (author)
Albin, MariaKarolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Arbetsorganisation och hälsa,Forskargrupper vid Lunds universitet,Environmental health and occupational health,Lund University Research Groups(Swepub:lu)ymed-mal (author)
Weiderpass, ElisabeteKarolinska Institutet,Karolinska Institute,University of Helsinki,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research (author)
Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre(Swepub:lu)med-khk (author)
German Cancer Research CentreNational Centre of Tumor Diseases (creator_code:org_t)

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In:European Journal of Cancer: Elsevier BV103, s. 1-60959-80491879-0852

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Occupational Hea ...

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