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Independent validat...
Independent validation of a pre-specified four-kallikrein marker model for prediction of adverse pathology and biochemical recurrence
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- Rasmussen, Martin (author)
- Aarhus University,Aarhus University Hospital
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- Fredsøe, Jacob (author)
- Aarhus University,Aarhus University Hospital
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- Tin, Amy L. (author)
- Memorial Sloan-Kettering Cancer Center
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- Vickers, Andrew J. (author)
- Memorial Sloan-Kettering Cancer Center
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- Ulhøi, Benedicte (author)
- Aarhus University Hospital
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- Borre, Michael (author)
- Aarhus University,Aarhus University Hospital
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- Eastham, James (author)
- Memorial Sloan-Kettering Cancer Center
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- Ehdaie, Behfar (author)
- Memorial Sloan-Kettering Cancer Center
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- Guillonneau, Bertrand (author)
- Charité - University Medicine Berlin,Memorial Sloan-Kettering Cancer Center
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- Laudone, Vincent (author)
- Memorial Sloan-Kettering Cancer Center
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- Scardino, Peter T. (author)
- Memorial Sloan-Kettering Cancer Center
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- Touijer, Karim (author)
- Memorial Sloan-Kettering Cancer Center
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- Sørensen, Karina D. (author)
- Aarhus University Hospital,Aarhus University
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- Lilja, Hans (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Clinical Chemistry, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Memorial Sloan-Kettering Cancer Center
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(creator_code:org_t)
- 2021-12-13
- 2022
- English.
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 126:7, s. 1004-1009
- Related links:
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http://dx.doi.org/10...
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Abstract
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- Background: Accurate markers for prostate cancer (PC) risk stratification could aid decision-making for initial management strategies. The 4Kscore has an undefined role in predicting outcomes after radical prostatectomy (RP). Methods: We included 1476 patients with 4Kscore measured prior to RP at two institutions. The 4Kscore was assessed for prediction of adverse pathology at RP and biochemical recurrence (BCR) relative to a clinical model. We pre-specified that all analyses would be assessed in biopsy Grade Group 1 (GG1) or 2 (GG2) PC patients, separately. Results: The 4Kscore increased discrimination for adverse pathology in all patients (delta area under the receiver operative curve (AUC) 0.009, 95% confidence interval (CI) 0.002, 0.016; clinical model AUC 0.767), driven by GG1 (delta AUC 0.040, 95% CI 0.006, 0.073) rather than GG2 patients (delta AUC 0.005, 95% CI −0.012, 0.021). Adding 4Kscore improved prediction of BCR in all patients (delta C-index 0.014, 95% CI 0.007, 0.021; preop-BCR nomogram C-index 0.738), again with larger changes in GG1 than in GG2. Conclusions: This study validates prior investigations on the use of 4Kscore in men with biopsy-confirmed PC. Men with GG1 PC and a high 4Kscore may benefit from additional testing to guide treatment selection. Further research is warranted regarding the value of the 4Kscore in men with biopsy GG2 PC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Rasmussen, Marti ...
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Fredsøe, Jacob
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Tin, Amy L.
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Vickers, Andrew ...
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Ulhøi, Benedicte
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Borre, Michael
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show more...
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Eastham, James
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Ehdaie, Behfar
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Guillonneau, Ber ...
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Laudone, Vincent
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Scardino, Peter ...
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Touijer, Karim
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Sørensen, Karina ...
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Lilja, Hans
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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British Journal ...
- By the university
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Lund University