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Genetic control of ...
Genetic control of collagen-induced arthritis in a cross with NOD and C57Bl/10 mice is dependent on gene regions coding for complement factor 5 and FcγRIIb and is not associated with loci controlling diabetes.
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- Johansson, Åsa (author)
- Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine
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- Sundler, Martin (author)
- Lund University
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- Kjellen, Peter (author)
- Lund University
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- Johannesson, Martina (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Cook, Andrew (author)
- Lund University
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- Lindqvist, Anna-Karin B. (author)
- Lund University
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- Nakken, Britt (author)
- University of Bergen
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- Bolstad, Anne Isine (author)
- University of Bergen
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- Skarstein, Kathrine (author)
- Uppsala University
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- Holmdahl, Rikard (author)
- Lund University
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(creator_code:org_t)
- 2001
- 2001
- English.
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In: European Journal of Immunology. - 1521-4141. ; 31:6, s. 1847-1856
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Abstract
Subject headings
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- The nonobese diabetic (NOD) mouse spontaneously develops autoimmune-mediated diseases such as diabetes and Sjögren′s syndrome. To investigate whether NOD genes also promote autoimmune-mediatedarthritis we established a NOD strain with an MHC class II fragment containing the Aq class II gene predisposing for collagen induced arthritis (NOD.Q). However, this mouse was resistant to arthritis in contrast to other Aq expressing strains such as B10.Q and DBA/1. To determine the major resistance factor/s, a genetic analysis was performed. (NOD.Q×B10.Q)F1 mice were resistant, whereas 27% of the (NOD.Q×B10.Q)F2 mice developed severe arthritis. Genetic mapping of 353 F2 mice revealed two loci associated with arthritis. One locus was found on chromosome 2 (LOD score 9.8), at the location of the complement factor 5 (C5) gene. The susceptibility allele was from B10.Q, which contains a productive C5 encoding gene in contrast to NOD.Q. The other significant locus was found on chromosome 1 (LOD score 5.6) close to the Fc-gamma receptor IIb gene, where NOD carried the susceptible allele. An interaction between the two loci was observed, indicating that they operate on the same or on interacting pathways. The genetic control of arthritis is unique in comparison to diabetes, since none of these loci have been identified in analysis of diabetes susceptibility.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Johansson, Åsa
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Sundler, Martin
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Kjellen, Peter
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Johannesson, Mar ...
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Cook, Andrew
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Lindqvist, Anna- ...
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show more...
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Nakken, Britt
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Bolstad, Anne Is ...
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Skarstein, Kathr ...
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Holmdahl, Rikard
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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European Journal ...
- By the university
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Lund University