Search: onr:"swepub:oai:lup.lub.lu.se:76d89309-9800-455e-9808-a901b2177489" >
Genetic Variation i...
Genetic Variation in the RANKL/RANK/OPG Signaling Pathway Is Associated With Bone Turnover and Bone Mineral Density in Men
-
Roshandel, Delnaz (author)
-
Holliday, Kate L. (author)
-
Pye, Stephen R. (author)
-
show more...
-
Boonen, Steven (author)
-
Borghs, Herman (author)
-
Vanderschueren, Dirk (author)
-
Huhtaniemi, Ilpo T. (author)
-
Adams, Judith E. (author)
-
Ward, Kate A. (author)
-
Bartfai, Gyorgy (author)
-
Casanueva, Felipe (author)
-
Finn, Joseph D. (author)
-
Forti, Gianni (author)
-
- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
-
Han, Thang S. (author)
-
Kula, Krzysztof (author)
-
Lean, Michael E. (author)
-
Pendleton, Neil (author)
-
Punab, Margus (author)
-
Silman, Alan J. (author)
-
Wu, Frederick C. (author)
-
Thomson, Wendy (author)
-
O'Neill, Terence W. (author)
-
show less...
-
(creator_code:org_t)
- 2010-03-04
- 2010
- English.
-
In: Journal of Bone and Mineral Research. - : Wiley. - 1523-4681 .- 0884-0431. ; 25:8, s. 1830-1838
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://onlinelibrar...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The aim of this study was to determine if single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG influence bone turnover and bone mineral density (BMD) in men. Pairwise tag SNPs (r(2) >= 0.8) were selected for RANKL, RANK, and OPG and their 10-kb flanking regions. Selected tag SNPs plus five SNPs near RANKL and OPG, associated with BMD in published genome-wide association studies (GWAS), were genotyped in 2653 men aged 40 to 79 years of age recruited for participation in a population-based study of male aging, the European Male Ageing Study (EMAS). N-terminal propeptide of type I procollagen (PINP) and C-terminal cross-linked telopeptide of type I collagen (CTX-I) serum levels were measured in all men. BMD at the calcaneus was estimated by quantitative ultrasound (QUS) in all men. Lumbar spine and total-hip areal BMD (BMDa) was measured by dual-energy X-ray absorptiometry (DXA) in a subsample of 620 men. Multiple OPG, RANK, and RANKL SNPs were associated with bone turnover markers. We also identified a number of SNPs associated with BMD, including rs2073618 in OPG and rs9594759 near RANKL. The minor allele of rs2073618 (C) was associated with higher levels of both PINP (beta = 1.83, p = .004) and CTX-I (beta = 17.59, p = 4.74 x 10(-4)), and lower lumbar spine BMDa (beta = -0.02, p = .026). The minor allele of rs9594759 (C) was associated with lower PINP (beta = -1.84, p = .003) and CTX-I (beta = -27.02, p = 6.06 x 10(-8)) and higher ultrasound BMD at the calcaneus (beta = 0.01, p = .037). Our findings suggest that genetic variation in the RANKL/RANK/OPG signaling pathway influences bone turnover and BMD in European men. (c) 2010 American Society for Bone and Mineral Research.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- BONE TURNOVER MARKERS
- SNPS
- OSTEOPOROSIS
- ASSOCIATION
- BONE
- DENSITOMETRY
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Roshandel, Delna ...
-
Holliday, Kate L ...
-
Pye, Stephen R.
-
Boonen, Steven
-
Borghs, Herman
-
Vanderschueren, ...
-
show more...
-
Huhtaniemi, Ilpo ...
-
Adams, Judith E.
-
Ward, Kate A.
-
Bartfai, Gyorgy
-
Casanueva, Felip ...
-
Finn, Joseph D.
-
Forti, Gianni
-
Giwercman, Aleks ...
-
Han, Thang S.
-
Kula, Krzysztof
-
Lean, Michael E.
-
Pendleton, Neil
-
Punab, Margus
-
Silman, Alan J.
-
Wu, Frederick C.
-
Thomson, Wendy
-
O'Neill, Terence ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
Journal of Bone ...
- By the university
-
Lund University