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Anionic nanoplastic...
Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation
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- Zhiyong, Liu (author)
- Duke University
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- Sokratian, Arpine (author)
- Duke University
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- Duda, Addison M. (author)
- Duke University
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- Xu, Enquan (author)
- Duke University
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- Stanhope, Christina (author)
- Duke University
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- Fu, Amber (author)
- Duke University
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- Strader, Samuel (author)
- Duke University
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- Li, Huizhong (author)
- Duke University
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- Yuan, Yuan (author)
- Duke University
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- Bobay, Benjamin G. (author)
- Duke University
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- Sipe, Joana (author)
- Duke University
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- Bai, Ketty (author)
- Duke University
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- Lundgaard, Iben (author)
- Lund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine
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- Liu, Na (author)
- Lund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Hernandez, Belinda (author)
- Duke University
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- Rickman, Catherine Bowes (author)
- Duke University
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- Miller, Sara E. (author)
- Duke University
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- West, Andrew B. (author)
- Aligning Science Across Parkinson's (ASAP) Collaborative Research Network,Duke University
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Science Advances. - 2375-2548. ; 9:46
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Recent studies have identified increasing levels of nanoplastic pollution in the environment. Here, we find that anionic nanoplastic contaminants potently precipitate the formation and propagation of α-synuclein protein fibrils through a high-affinity interaction with the amphipathic and non-amyloid component (NAC) domains in α-synuclein. Nanoplastics can internalize in neurons through clathrin-dependent endocytosis, causing a mild lysosomal impairment that slows the degradation of aggregated α-synuclein. In mice, nanoplastics combine with α-synuclein fibrils to exacerbate the spread of α-synuclein pathology across interconnected vulnerable brain regions, including the strong induction of α-synuclein inclusions in dopaminergic neurons in the substantia nigra. These results highlight a potential link for further exploration between nanoplastic pollution and α-synuclein aggregation associated with Parkinson’s disease and related dementias.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Zhiyong, Liu
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Sokratian, Arpin ...
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Duda, Addison M.
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Xu, Enquan
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Stanhope, Christ ...
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Fu, Amber
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show more...
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Strader, Samuel
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Li, Huizhong
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Yuan, Yuan
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Bobay, Benjamin ...
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Sipe, Joana
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Bai, Ketty
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Lundgaard, Iben
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Liu, Na
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Hernandez, Belin ...
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Rickman, Catheri ...
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Miller, Sara E.
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West, Andrew B.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Science Advances
- By the university
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Lund University