onr:"swepub:oai:lup.lub.lu.se:772020b5-4a9e-4ea3-8e81-88a63358a501"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04047naa a2200337 4500 | |
| 001 | oai:lup.lub.lu.se:772020b5-4a9e-4ea3-8e81-88a63358a501 | |
| 003 | SwePub | |
| 008 | 160404s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/20084672 URI |
| 024 | 7 | a https://doi.org/10.1002/bjs.75742 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a for2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Ansari, Danielu Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-dar |
| 245 | 1 0 | a Systematic review of immunohistochemical biomarkers to identify prognostic subgroups of patients with pancreatic cancer. |
| 264 | c 2011-06-06 | |
| 264 | 1 | b Oxford University Press (OUP),c 2011 |
| 520 | a BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis. There is a need to identify prognostic subtypes of PDAC to predict clinical and therapeutic outcomes accurately, and define novel therapeutic targets. The purpose of this review was to provide a systematic summary and review of available data on immunohistochemical (IHC) prognostic and predictive markers in patients with PDAC. METHODS: Relevant articles in English published between January 1990 and June 2010 were obtained from PubMed searches. Other articles identified from cross-checking references and additional sources were reviewed. The inclusion was limited to studies evaluating IHC markers in a multivariable setting. RESULTS: Database searches identified 76 independent prognostic and predictive molecular markers implicated in pancreatic tumour growth, apoptosis, angiogenesis, invasion and resistance to chemotherapy. Of these, 11 markers (Ki-67, p27, p53, transforming growth factor β1, Bcl-2, survivin, vascular endothelial growth factor, cyclo-oxygenase 2, CD34, S100A4 and human equilibrative nucleoside transporter 1) provided independent prognostic or predictive information in two or more separate studies. CONCLUSION: None of the molecular markers described can be recommended for routine clinical use as they were identified in small cohorts and there were inconsistencies between studies. Their prognostic and predictive values need to be validated further in prospective multicentre studies in larger patient populations. A panel of molecular markers may become useful in predicting individual patient outcome and directing novel types of intervention. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 700 | 1 | a Rosendahl, Annu Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-aro |
| 700 | 1 | a Elebro, Ju Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-jce |
| 700 | 1 | a Andersson, Rolandu Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kir-ran |
| 710 | 2 | a Kirurgi, Lundb Sektion V4 org |
| 773 | 0 | t British Journal of Surgeryd : Oxford University Press (OUP)g 98, s. 1041-1055q 98<1041-1055x 1365-2168x 0007-1323 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/21644238?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1002/bjs.7574y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/2008467 |
| 856 | 4 8 | u https://doi.org/10.1002/bjs.7574 |
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