Search: onr:"swepub:oai:lup.lub.lu.se:7736ec7d-320e-4b14-8090-189de70974ac" >
Psychosis in System...
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Hanly, John G.Dalhousie University
(author)
Psychosis in Systemic Lupus Erythematosus : Results From an International Inception Cohort Study
- Article/chapterEnglish2019
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LIBRIS-ID:oai:lup.lub.lu.se:7736ec7d-320e-4b14-8090-189de70974ac
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https://lup.lub.lu.se/record/7736ec7d-320e-4b14-8090-189de70974acURI
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https://doi.org/10.1002/art.40764DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140181167URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Objective: To determine, in a large, multiethnic/multiracial, prospective inception cohort of patients with systemic lupus erythematosus (SLE), the frequency, attribution, clinical, and autoantibody associations with lupus psychosis and the short- and long-term outcomes as assessed by physicians and patients. Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including psychosis. Scores on the Systemic Lupus Erythematosus Disease Activity Index 2000, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, and the Short Form 36 (SF-36) were recorded. Time to event and linear regressions were used as appropriate. Results: Of 1,826 SLE patients, 88.8% were female and 48.8% were Caucasian. The mean ± SD age was 35.1 ± 13.3 years, the mean ± SD disease duration was 5.6 ± 4.2 months, and the mean ± SD follow-up period was 7.4 ± 4.5 years. There were 31 psychotic events in 28 of 1,826 patients (1.53%), and most patients had a single event (26 of 28 [93%]). In the majority of patients (20 of 25 [80%]) and events (28 of 31 [90%]), psychosis was attributed to SLE, usually either in the year prior to or within 3 years of SLE diagnosis. Positive associations (hazard ratios [HRs] and 95% confidence intervals [95% CIs]) with lupus psychosis were previous SLE NP events (HR 3.59 [95% CI 1.16–11.14]), male sex (HR 3.0 [95% CI 1.20–7.50]), younger age at SLE diagnosis (per 10 years) (HR 1.45 [95% CI 1.01–2.07]), and African ancestry (HR 4.59 [95% CI 1.79–11.76]). By physician assessment, most psychotic events resolved by the second annual visit following onset, in parallel with an improvement in patient-reported SF-36 summary and subscale scores. Conclusion: Psychosis is an infrequent manifestation of NPSLE. Generally, it occurs early after SLE onset and has a significant negative impact on health status. As determined by patient and physician report, the short- and long-term outlooks are good for most patients, although careful follow-up is required.
Subject headings and genre
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Li, QiujuUniversity of Cambridge
(author)
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Su, LiUniversity of Cambridge
(author)
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Urowitz, Murray B.University of Toronto
(author)
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Gordon, CarolineUniversity of Birmingham
(author)
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Bae, Sang CheolHanyang University
(author)
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Romero-Diaz, JuanitaInstituto Nacional de Ciencias Médicas y Nutrición
(author)
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Sanchez-Guerrero, JorgeUniversity of Toronto
(author)
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Bernatsky, SashaMcGill University
(author)
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Clarke, Ann E.University of Calgary
(author)
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Wallace, Daniel J.Jonsson Comprehensive Cancer Center
(author)
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Isenberg, David A.University College London,Indian Institute of Technology
(author)
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Rahman, AnisurUniversity College London
(author)
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Merrill, Joan T.Oklahoma Medical Research Foundation
(author)
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Fortin, Paul R.Laval University
(author)
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Gladman, Dafna D.University of Toronto
(author)
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Bruce, Ian N.Christie NHS Foundation Trust
(author)
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Petri, MichelleJohns Hopkins University School of Medicine
(author)
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Ginzler, Ellen MSUNY Downstate Health Sciences University,Feinstein Institute for Medical Research
(author)
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Dooley, M. A.University of North Carolina
(author)
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Steinsson, KristjanNational University Hospital of Iceland
(author)
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Ramsey-Goldman, RosalindNorthwestern University
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Zoma, Asad A.Hairmyres Hospital
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Manzi, SusanAllegheny Health Network
(author)
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Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni
(author)
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Jonsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)reum-ajo
(author)
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Khamashta, Munther A.Guy's and St Thomas' NHS Foundation Trust
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Alarcón, Graciela S.University of Alabama
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van Vollenhoven, Ronald F.Karolinska Institutet,Karolinska Institute
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Aranow, CynthiaFeinstein Institute for Medical Research
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Mackay, MegganFeinstein Institute for Medical Research
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Ruiz-Irastorza, GuillermoUniversity of the Basque Country
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Ramos-Casals, ManuelHospital Clínic of Barcelona
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Lim, S. SamEmory University
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Inanc, MuratIstanbul University
(author)
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Kalunian, Kenneth C.
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Jacobsen, SorenCopenhagen University Hospital
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Peschken, Christine A.University of Manitoba
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Kamen, Diane L.Medical University of South Carolina
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Askanase, AncaIndian Institute of Technology
(author)
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Theriault, ChrisDalhousie University
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Farewell, VernonUniversity of Cambridge
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Dalhousie UniversityUniversity of Cambridge
(creator_code:org_t)
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In:Arthritis and Rheumatology: Wiley71:2, s. 281-2892326-51912326-5205
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Hanly, John G.
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Li, Qiuju
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Su, Li
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Urowitz, Murray ...
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Gordon, Caroline
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Bae, Sang Cheol
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Romero-Diaz, Jua ...
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Sanchez-Guerrero ...
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Bernatsky, Sasha
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Clarke, Ann E.
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Wallace, Daniel ...
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Isenberg, David ...
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Rahman, Anisur
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Merrill, Joan T.
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Fortin, Paul R.
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Gladman, Dafna D ...
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Bruce, Ian N.
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Petri, Michelle
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Ginzler, Ellen M
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Dooley, M. A.
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Steinsson, Krist ...
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Ramsey-Goldman, ...
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Zoma, Asad A.
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Manzi, Susan
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Nived, Ola
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Jonsen, Andreas
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Khamashta, Munth ...
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Alarcón, Graciel ...
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van Vollenhoven, ...
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Lim, S. Sam
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Inanc, Murat
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Kalunian, Kennet ...
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Jacobsen, Soren
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Peschken, Christ ...
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Kamen, Diane L.
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Askanase, Anca
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Theriault, Chris
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Farewell, Vernon
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Karolinska Institutet