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Receptors involved in the nervous system regulation of polyamine metabolism in rat salivary glands
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Ekström, J. (author)
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- Månsson, B (author)
- Malmö University
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Tobin, G (author)
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- Nilsson, B O (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Kärlfysiologi,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Vascular Physiology,Lund University Research Groups
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Rosengren, Elsa (author)
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(creator_code:org_t)
- Wiley, 1989
- 1989
- English.
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In: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 135:3, s. 61-255
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Polyamines are important for protein synthesis and tissue growth. In rat salivary glands, the activity of ornithine decarboxylase (ODC), the enzyme catalysing the formation of putrescine, and the content of putrescine, spermidine, spermine and N1-acetylspermidine were assayed after parasympathetic or sympathetic nerve stimulation in the presence of various autonomic receptor blockers. Increases in ODC activity occurred on activation of non-adrenergic and non-cholinergic receptors in response to parasympathetic nerve stimulation and on activation of alpha(alpha 1)- as well as of beta(beta 1)-adrenoceptors in response to sympathetic nerve stimulation. Moreover, in parotid glands, a beta(beta 1)-adrenoceptor-mediated inverse pathway for putrescine formation seemed to exist: from spermidine via N1-acetylspermidine.
Keyword
- Animals
- Atropine
- Dihydroergotamine
- Male
- Ornithine Decarboxylase
- Parasympathetic Nervous System
- Phentolamine
- Propranolol
- Putrescine
- Rats
- Rats, Inbred Strains
- Salivary Glands
- Spermidine
- Spermine
- Sympathetic Nervous System
- Yohimbine
Publication and Content Type
- art (subject category)
- ref (subject category)
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