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Resveratrol suppres...
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Dao, Trong TuanNational Institute of Medicinal Materials, Vietnam
(author)
Resveratrol suppressed lps-induced cox-2 VIA miR-146a-5p inhibition in raw246.7 cells
- Article/chapterEnglish2017
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LIBRIS-ID:oai:lup.lub.lu.se:77895655-ae35-45c8-9d07-ca399c6bae42
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https://lup.lub.lu.se/record/77895655-ae35-45c8-9d07-ca399c6bae42URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Trans-resveratrol (Res) is a well-known natural stilbene frequently found in grapes which have been reported to possess antioxidant, anti-cancer activities and inhibited COX-2 expression. MicroRNAs (miRNAs) are short endogenous non-coding RNAs involved in the regulation of mRNA stability and protein synthesis. In our research, resveratrol isolated from Vitis heyneana Roem. & Schult Vitis heyneana was observed to suppress lipopolysaccharides (LPS)-induced COX-2 expression in Raw264.7 cells in a dose dependent manner. Using qPCR it was revealed that LPS induced the expression of miR-25, miR- 125a, miR-125b, miR-146a-5p, miR-146a-3p and miR-455. However, we only observed miR-146a-5p expression significantly decreased in resveratrol compared to untreated-control group. In addition, resveratrol abrogated the effect of miR-146a-5p mimic induced-COX-2 expression in Raw264.7 cells. Taken together, this study demonstrated for the first time the involvement of miR-146a-5p in resveratrol inhibited LPS-induced COX-2 expression in Raw264.7 cells.
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Ha, Do ThiNational Institute of Medicinal Materials, Vietnam
(author)
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Hien Tran, ThiLund University,Lunds universitet,Molekylär kärlfysiologi,Forskargrupper vid Lunds universitet,Molecular Vascular Physiology,Lund University Research Groups,Thai Binh University of Medicine and Pharmacy(Swepub:lu)med-thr
(author)
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Binh, Bui ThiThai Binh University of Medicine and Pharmacy
(author)
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Phuong, Tran ThiChonnam National University
(author)
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Long, Phung ThanhNational Institute of Medicinal Materials, Vietnam
(author)
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Thu, Nguyen BichNational Institute of Medicinal Materials, Vietnam
(author)
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Que, Do Thi NguyetHanoi University of Pharmacy
(author)
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Khoi, Nguyen MinhNational Institute of Medicinal Materials, Vietnam
(author)
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Dung, Le VietNational Institute of Medicinal Materials, Vietnam
(author)
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Ngoc, Tran MinhNational Institute of Medicinal Materials, Vietnam
(author)
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National Institute of Medicinal Materials, VietnamMolekylär kärlfysiologi
(creator_code:org_t)
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In:Farmacia65:2, s. 214-2180014-8237
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Dao, Trong Tuan
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Ha, Do Thi
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Hien Tran, Thi
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Binh, Bui Thi
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Long, Phung Than ...
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Thu, Nguyen Bich
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Que, Do Thi Nguy ...
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Ngoc, Tran Minh
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Farmacia
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