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Pulseq-CEST : Towar...
Pulseq-CEST : Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard
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- Herz, Kai (author)
- Max Planck Institute for Biological Cybernetics
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- Mueller, Sebastian (author)
- Max Planck Institute for Biological Cybernetics
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- Perlman, Or (author)
- Massachusetts General Hospital
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- Zaitsev, Maxim (author)
- Medical University of Vienna
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- Knutsson, Linda (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Johns Hopkins University School of Medicine
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- Sun, Phillip Zhe (author)
- Emory University
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- Zhou, Jinyuan (author)
- Johns Hopkins University
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- van Zijl, Peter (author)
- Johns Hopkins University
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- Heinecke, Kerstin (author)
- Physikalisch-Technische Bundesanstalt
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- Schuenke, Patrick (author)
- Physikalisch-Technische Bundesanstalt
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- Farrar, Christian T (author)
- Massachusetts General Hospital
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- Schmidt, Manuel (author)
- University Hospital Erlangen
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- Dörfler, Arnd (author)
- University Hospital Erlangen
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- Scheffler, Klaus (author)
- Max Planck Institute for Biological Cybernetics
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- Zaiss, Moritz (author)
- Max Planck Institute for Biological Cybernetics,Friedrich-Alexander University Erlangen-Nürnberg
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(creator_code:org_t)
- 2021-05-07
- 2021
- English.
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In: Magnetic Resonance in Medicine. - : Wiley. - 1522-2594 .- 0740-3194. ; 86:4, s. 1845-1858
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Abstract
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- PURPOSE: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols.METHODS: We present the benefits of such a standard in three ways: (1) an open database on GitHub, where fully defined, human-readable CEST protocols can be shared; (2) an open-source Bloch-McConnell simulation to test and optimize CEST preparation periods in silico; and (3) a hybrid MR sequence that plays out the CEST preparation period and can be combined with any existing readout module.RESULTS: The exact definition of the CEST preparation period, in combination with the flexible simulation, leads to a good match between simulations and measurements. The standard allowed finding consensus on three amide proton transfer-weighted protocols that could be compared in healthy subjects and a tumor patient. In addition, we could show coherent multisite results for a sophisticated CEST method, highlighting the benefits regarding protocol sharing and reproducibility.CONCLUSION: With Pulseq-CEST, we provide a straightforward approach to standardize, share, simulate, and measure different CEST preparation schemes, which are inherently completely defined.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
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- By the author/editor
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Herz, Kai
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Mueller, Sebasti ...
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Perlman, Or
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Zaitsev, Maxim
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Knutsson, Linda
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Sun, Phillip Zhe
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show more...
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Zhou, Jinyuan
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van Zijl, Peter
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Heinecke, Kersti ...
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Schuenke, Patric ...
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Farrar, Christia ...
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Schmidt, Manuel
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Dörfler, Arnd
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Scheffler, Klaus
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Zaiss, Moritz
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Other Physics To ...
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Magnetic Resonan ...
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Lund University