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Typical ultrasound ...
Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding
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- Van Den Bosch, T. (author)
- Catholic University of Leuven,University Hospitals Leuven
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- Verbakel, J. Y. (author)
- Catholic University of Leuven
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- Valentin, L. (author)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital
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- Wynants, L. (author)
- Catholic University of Leuven,Maastricht University
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- De Cock, B. (author)
- Catholic University of Leuven
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- Pascual, M. A. (author)
- University Hospital Dexeus
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- Leone, F. P.G. (author)
- University of Milan
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- Sladkevicius, P. (author)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital
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- Alcazar, J. L. (author)
- University Clinic of Navarra
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- Votino, A. (author)
- University Hospital Brugmann
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- Fruscio, R. (author)
- University of Milano-Bicocca,San Gerardo Hospital
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- Lanzani, C. (author)
- University of Milan
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- Van Holsbeke, C. (author)
- Hospital Oost-Limburg
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- Rossi, A. (author)
- University of Udine
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- Jokubkiene, L. (author)
- Lund University,Lunds universitet,Urogynekologi och reproduktionsfarmakologi,Forskargrupper vid Lunds universitet,Urogynaecology and Reproductive Pharmacology,Lund University Research Groups,Skåne University Hospital
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- Kudla, M. (author)
- Medical University of Silesia
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- Jakab, A. (author)
- University of Debrecen
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- Domali, E. (author)
- National and Kapodistrian University of Athens,Alexandra Hospital, Athens
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- Epstein, E. (author)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- Van Pachterbeke, C. (author)
- University Hospital Brugmann
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- Bourne, T. (author)
- Catholic University of Leuven,University Hospitals Leuven,Queen Charlotte's and Chelsea Hospital
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- Van Calster, B. (author)
- Catholic University of Leuven
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- Timmerman, D. (author)
- Catholic University of Leuven,University Hospitals Leuven
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(creator_code:org_t)
- 2021-01-02
- 2021
- English 9 s.
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In: Ultrasound in Obstetrics and Gynecology. - : Wiley. - 0960-7692 .- 1469-0705. ; 57:1, s. 164-172
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Abstract
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- Objective: To describe the ultrasound features of different endometrial and other intracavitary pathologies inpre- and postmenopausal women presenting with abnormal uterine bleeding, using the International Endometrial Tumor Analysis (IETA) terminology. Methods: This was a prospective observational multicenter study of consecutive women presenting with abnormal uterine bleeding. Unenhanced sonography with color Doppler and fluid-instillation sonography were performed. Endometrial sampling was performed according to each center's local protocol. The histological endpoints were cancer, atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia (EIN), endometrial atrophy, proliferative or secretory endometrium, endometrial hyperplasia without atypia, endometrial polyp, intracavitary leiomyoma and other. For fluid-instillation sonography, the histological endpoints were endometrial polyp, intracavitary leiomyoma and cancer. For each histological endpoint, we report typical ultrasound features using the IETA terminology. Results: The database consisted of 2856 consecutive women presenting with abnormal uterine bleeding. Unenhanced sonography with color Doppler was performed in all cases and fluid-instillation sonography in 1857. In 2216 women, endometrial histology was available, and these comprised the study population. Median age was 49 years (range, 19–92 years), median parity was 2 (range, 0–10) and median body mass index was 24.9 kg/m2 (range, 16.0–72.1 kg/m2). Of the study population, 843 (38.0%) women were postmenopausal. Endometrial polyps were diagnosed in 751 (33.9%) women, intracavitary leiomyomas in 223 (10.1%) and endometrial cancer in 137 (6.2%). None (0% (95% CI, 0.0–5.5%)) of the 66 women with endometrial thickness < 3 mm had endometrial cancer or atypical hyperplasia/EIN. Endometrial cancer or atypical hyperplasia/EIN was found in three of 283 (1.1% (95% CI, 0.4–3.1%)) endometria with a three-layer pattern, in three of 459 (0.7% (95% CI, 0.2–1.9%)) endometria with a linear endometrial midline and in five of 337 (1.5% (95% CI, 0.6–3.4%)) cases with a single vessel without branching on unenhanced ultrasound. Conclusions: The typical ultrasound features of endometrial cancer, polyps, hyperplasia and atrophy and intracavitary leiomyomas, are described using the IETA terminology. The detection of some easy-to-assess IETA features (i.e. endometrial thickness < 3 mm, three-layer pattern, linear midline and single vessel without branching) makes endometrial cancer unlikely.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- cancer
- diagnosis
- endometrium
- hyperplasia
- IETA
- leiomyoma
- polyp
- sonohysterography
- ultrasonography
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Van Den Bosch, T ...
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Verbakel, J. Y.
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Valentin, L.
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Wynants, L.
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De Cock, B.
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Pascual, M. A.
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show more...
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Leone, F. P.G.
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Sladkevicius, P.
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Alcazar, J. L.
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Votino, A.
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Fruscio, R.
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Lanzani, C.
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Van Holsbeke, C.
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Rossi, A.
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Jokubkiene, L.
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Kudla, M.
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Jakab, A.
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Domali, E.
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Epstein, E.
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Van Pachterbeke, ...
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Bourne, T.
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Van Calster, B.
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Timmerman, D.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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Ultrasound in Ob ...
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Lund University
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Karolinska Institutet