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Who is enrolling? T...
Who is enrolling? The path to monitoring in type 1 diabetes trialnet’s pathway to prevention
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- Sims, Emily K. (author)
- Indiana University
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- Geyer, Susan (author)
- University of South Florida
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- Johnson, Suzanne Bennett (author)
- Florida State University
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- Libman, Ingrid (author)
- University of Pittsburgh,Children's Hospital of Pittsburgh of UPMC
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- Jacobsen, Laura M. (author)
- University of Florida
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- Boulware, David (author)
- University of South Florida
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- Rafkin, Lisa E. (author)
- University of Miami
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- Matheson, Della (author)
- University of Miami
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- Atkinson, Mark A. (author)
- University of Florida
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- Rodriguez, Henry (author)
- University of Miami
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- Spall, Maria (author)
- Indiana University
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- Larsson, Helena Elding (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital
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- Wherrett, Diane K. (author)
- University of Toronto,Hospital for Sick Children, Toronto
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- Greenbaum, Carla J. (author)
- Benaroya Research Institute
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- Krischer, Jeffrey (author)
- University of South Florida
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- DiMeglio, Linda A. (author)
- Indiana University
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(creator_code:org_t)
- 2019-09-26
- 2019
- English 9 s.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 42:12, s. 2228-2236
- Related links:
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http://dx.doi.org/10...
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https://care.diabete...
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https://doi.org/10.2...
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Abstract
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- OBJECTIVE To better understand potential facilitators of individual engagement in type 1 diabetes natural history and prevention studies through analysis of enrollment data in the TrialNet Pathway to Prevention (PTP) study. RESEARCH DESIGN AND METHODS We used multivariable logistic regression models to examine continued engagement of eligible participants at two time points: 1) the return visit after screening to confirm an initial autoantibody-positive (Ab1) test result and 2) the initial oral glucose tolerance test (OGTT) for enrollment into the monitoring protocol. RESULTS Of 5,387 subjects who screened positive for a single autoantibody (Ab), 4,204 (78%) returned for confirmatory Ab testing. Younger age was associated with increased odds of returning for Ab confirmation (age <12 years vs. >18 years: odds ratio [OR] 2.12, P < 0.0001). Racial and ethnic minorities were less likely to return for confirmation, particularly nonwhite non-Hispanic (OR 0.50, P < 0.0001) and Hispanic (OR 0.69, P 5 0.0001) relative to non-Hispanic white subjects. Of 8,234 subjects, 5,442 (66%) were identified as eligible to be enrolled in PTP OGTT monitoring. Here, younger age and identification as multiple Ab1 were associated with increased odds of returning for OGTT monitoring (age <12 years vs. >18 years: OR 1.43, P < 0.0001; multiple Ab1: OR 1.36, P < 0.0001). Parents were less likely to enroll into monitoring than other relatives (OR 0.78, P 5 0.004). Site-specific factors, including site volume and U.S. site versus international site, were also associated with differences in rates of return for Ab1 confirmation and enrollment into monitoring. CONCLUSIONS These data confirm clear differences between successfully enrolled populations and those lost to follow-up, which can serve to identify strategies to increase ongoing participation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Sims, Emily K.
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Geyer, Susan
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Johnson, Suzanne ...
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Libman, Ingrid
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Jacobsen, Laura ...
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Boulware, David
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show more...
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Rafkin, Lisa E.
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Matheson, Della
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Atkinson, Mark A ...
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Rodriguez, Henry
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Spall, Maria
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Larsson, Helena ...
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Wherrett, Diane ...
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Greenbaum, Carla ...
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Krischer, Jeffre ...
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DiMeglio, Linda ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes Care
- By the university
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Lund University