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Coeliac patients de...
Coeliac patients detected during type 1 diabetes surveillance had similar issues to those diagnosed on a clinical basis
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- Laitinen, Anna U. (author)
- Tampere University Hospital
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- Agardh, Daniel (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Kivelä, Laura (author)
- Tampere University Hospital
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- Huhtala, Heini (author)
- University of Tampere
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- Lähdeaho, Marja Leena (author)
- Tampere University Hospital
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- Kaukinen, Katri (author)
- Tampere University Hospital
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- Kurppa, Kalle (author)
- Tampere University Hospital
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(creator_code:org_t)
- 2017-01-13
- 2017
- English.
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In: Acta Paediatrica, International Journal of Paediatrics. - : Wiley. - 0803-5253. ; 106:4, s. 639-646
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Abstract
Subject headings
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- Aim: Screening children with type 1 diabetes for coeliac disease is controversial, because they often appear asymptomatic. Our aim was to establish whether active screening should be recommended. Methods: This study focused on 22 children whose coeliac disease was detected by serological screening during diabetes surveillance and 498 children diagnosed because of a clinical suspicion. We compared the clinical and histological data at diagnosis and the children's adherence and responses to a gluten-free diet. Results: The serological screening group suffered less from decreased growth (p = 0.016) and clinical symptoms (p < 0.001) at diagnosis than the clinical group. The groups did not differ in terms of age at diagnosis (p = 0.903), gender (p = 0.353), anaemia (p = 0.886), endomysial antibody titres (p = 0.789) and the severity of small-bowel mucosal atrophy (p = 0.104). They also showed equal adherence (p = 0.086) and clinical responses (p = 0.542) to a gluten-free diet after a median follow-up of 13 months. Conclusion: Coeliac patients detected during diabetes surveillance had signs of malabsorption and advanced mucosal damage that was similar to those diagnosed on a clinical basis. They often suffered from unrecognised gluten-dependent symptoms and showed excellent adherence and responses to a gluten-free diet. Our findings support active screening for coeliac disease in patients with type 1 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Clinical diagnosis
- Coeliac disease
- Routine surveillance
- Type 1 diabetes
- Villous atrophy
Publication and Content Type
- art (subject category)
- ref (subject category)
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