BDNF makes cultured dentate granule cells more resistant to hypoglycaemic damage

Kokaia, Z (author): Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neural stamcellsbiologi och terapi,Forskargrupper vid Lunds universitet,Stem Cells & Restorative Neurology,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neural stem cell biology and therapy,Lund University Research Groups,Skåne University Hospital,Institutionen för kliniska vetenskaper, Lund,Department of Clinical Sciences, Lund

Othberg, A (author): Lund University,Lunds universitet,Neuronano Research Center (NRC),Forskargrupper vid Lunds universitet,Lund University Research Groups

Kokaia, M (author): Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurologi, Lund,Institutionen för kliniska vetenskaper, Lund,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neurology, Lund,Department of Clinical Sciences, Lund,Institutionen för kliniska vetenskaper, Lund,Department of Clinical Sciences, Lund

Lindvall, O (author): Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurogenes och Cellterapi,Forskargrupper vid Lunds universitet,Stem Cells & Restorative Neurology,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neurogenesis and cell therapy,Lund University Research Groups,Institutionen för kliniska vetenskaper, Lund,Department of Clinical Sciences, Lund

SanMartin, Agneta (author): Lund University,Lunds universitet,Neuronano Research Center (NRC),Forskargrupper vid Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund University Research Groups,Department of Clinical Sciences, Lund,Faculty of Medicine

(creator_code:org_t)

Ovid Technologies (Wolters Kluwer Health), 1994
1994
English 4 s.
In: NeuroReport. - : Ovid Technologies (Wolters Kluwer Health). - 0959-4965 .- 1473-558X. ; 5:10, s. 4-1241

Related links:: http://dx.doi.org/10...; show more...; https://lup.lub.lu.s...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Abstract Subject headings

The aim of this study was to explore whether brain-derived neurotrophic factor (BDNF) can improve neuronal survival in cell cultures of rat dentate gyrus subjected to a hypoglycaemic insult. Glucose deprivation for 15 h caused severe neuronal loss (about 70%). BDNF added either 24 h before or 4 h after onset of hypoglycaemia completely protected granule cells against this insult-induced damage. Nerve growth factor (NGF) had similar effects. These findings support the hypothesis that the rapid upregulation of BDNF mRNA in dentate granule cells after brief periods of hypoglycaemic coma and other insults is a local protective mechanism.

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)

By the author/editor: Kokaia, Z; Othberg, A; Kokaia, M; Lindvall, O; SanMartin, Agnet ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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