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Differential effect...
Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells
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- Abreu, Soraia Carvalho (author)
- University of Vermont,Federal University of Rio de Janeiro
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- Hampton, Thomas H (author)
- Dartmouth College
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- Hoffman, Evan (author)
- University of Vermont
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- Dearborn, Jacob (author)
- University of Vermont
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- Ashare, Alix (author)
- Dartmouth College,Dartmouth-Hitchcock Medical Center
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- Singh Sidhu, Karatatiwant (author)
- University of Vermont
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- Matthews, Dwight E (author)
- University of Vermont
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- McKenna, David H. (author)
- University of Minnesota
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- Amiel, Eyal (author)
- University of Vermont
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- Barua, Jayita (author)
- University of Vermont
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- Krasnodembskaya, Anna (author)
- Queen's University Belfast
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- English, Karen (author)
- Maynooth University
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- Mahon, Bernard Patrick (author)
- Maynooth University
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- Santos, Claudia Dos (author)
- Saint Michael's Hospital,University of Toronto
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- Cruz, Fernanda F (author)
- National Institute of Science and Technology in Regenerative Medicine (INCT-REGENERA),Federal University of Rio de Janeiro
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- Chambers, Daniel C. (author)
- The Prince Charles Hospital,University of Queensland
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- Liu, Kathleen D (author)
- University of California, San Francisco
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- Matthay, Michael A. (author)
- University of California, San Francisco
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- Cramer, Robert A (author)
- Dartmouth College
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- Stanton, Bruce A (author)
- Dartmouth College
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- Rocco, Patricia R M (author)
- National Institute of Science and Technology in Regenerative Medicine (INCT-REGENERA),Federal University of Rio de Janeiro
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- Wargo, Matthew J. (author)
- University of Vermont
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- Weiss, Daniel J. (author)
- University of Vermont
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- Rolandsson Enes, Sara (author)
- Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups,University of Vermont
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(creator_code:org_t)
- American Physiological Society, 2020
- 2020
- English.
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In: American Journal of Physiology: Lung Cellular and Molecular Physiology. - : American Physiological Society. - 1040-0605 .- 1522-1504.
- Related links:
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http://dx.doi.org/10...
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Abstract
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- Growing evidence demonstrates that human mesenchymal stromal cells (MSCs) modify their in vivo anti-inflammatory actions depending on the specific inflammatory environment encountered. Understanding this better is crucial to refine MSC-based cell therapies for lung and other diseases. Using acute exacerbations of cystic fibrosis (CF) lung disease as a model, the effects of ex vivo MSC exposure to clinical bronchoalveolar lavage fluid (BALF) samples, as a surrogate for the in vivo clinical lung environment, on MSC viability, gene expression, secreted cytokines, and mitochondrial function was compared to effects of BALF collected from healthy volunteers. CF BALF samples which cultured positive for Aspergillus sp. (Asp) induced rapid MSC death, usually within several hours of exposure. Further analyses suggested the fungal toxin gliotoxin as a potential mediator contributing to CF BALF-induced MSC death. RNA sequencing analyses of MSCs exposed to either Asp+ or Asp- CF BALF samples identified a number of differentially expressed transcripts, including those involved in interferon-signaling, anti-microbial gene expression, and cell death. Toxicity did not correlate with bacterial lung infections. These results suggest that the potential use of MSC-based cell therapies for CF or other lung diseases may not be warranted in the presence of Aspergillus.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Abreu, Soraia Ca ...
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Hampton, Thomas ...
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Hoffman, Evan
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Dearborn, Jacob
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Ashare, Alix
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Singh Sidhu, Kar ...
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Matthews, Dwight ...
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McKenna, David H ...
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Amiel, Eyal
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Barua, Jayita
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Krasnodembskaya, ...
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English, Karen
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Mahon, Bernard P ...
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Santos, Claudia ...
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Cruz, Fernanda F
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Chambers, Daniel ...
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Liu, Kathleen D
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Matthay, Michael ...
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Cramer, Robert A
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Stanton, Bruce A
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Rocco, Patricia ...
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Wargo, Matthew J ...
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Weiss, Daniel J.
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Rolandsson Enes, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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American Journal ...
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Lund University