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Plasma fetuin-A con...
Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer
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Nimptsch, Katharina (author)
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Aleksandrova, Krasimira (author)
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Boeing, Heiner (author)
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show more...
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Janke, Juergen (author)
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Lee, Young-Ae (author)
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Jenab, Mazda (author)
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Kong, So Yeon (author)
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Tsilidis, Konstantinos K. (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Bueno-de-Mesquita, H. B(As) (author)
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Siersema, Peter D. (author)
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Jansen, Eugene H. J. M. (author)
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Trichopoulou, Antonia (author)
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Tjonneland, Anne (author)
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Olsen, Anja (author)
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Wu, Chunsen (author)
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Overvad, Kim (author)
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Boutron-Ruault, Marie-Christine (author)
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Racine, Antoine (author)
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Freisling, Heinz (author)
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Katzke, Verena (author)
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Kaaks, Rudolf (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Severi, Gianluca (author)
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Naccarati, Alessio (author)
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Mattiello, Amalia (author)
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Palli, Domenico (author)
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Grioni, Sara (author)
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Tumino, Rosario (author)
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Peeters, Petra H. (author)
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- Ljuslinder, Ingrid (author)
- Umeå universitet,Onkologi
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- Nyström, Hanna (author)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
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- Brändstedt, Jenny (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Sanchez, Maria-Jose (author)
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Gurrea, Aurelio Barricarte (author)
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Bonet, Catalina Bonet (author)
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Chirlaque, Maria-Dolores (author)
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Dorronsoro, Miren (author)
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Quiros, Jose Ramon (author)
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Travis, Ruth C. (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Riboli, Elio (author)
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Gunter, Marc J. (author)
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Pischon, Tobias (author)
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(creator_code:org_t)
- 2015-02-05
- 2015
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 137:4, s. 911-920
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Abstract
Subject headings
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- Fetuin-A, also referred to as alpha 2-Heremans-Schmid glycoprotein (AHSG), is a liver protein known to inhibit insulin actions. Hyperinsulinemia is a possible risk factor for colorectal cancer; however, the role of fetuin-A in the development of colorectal cancer is unclear. We investigated the association between circulating fetuin-A and colorectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. Fetuin-A concentrations were measured in prediagnostic plasma samples from 1,367 colorectal cancer cases and 1,367 matched controls. In conditional logistic regression models adjusted for potential confounders, the estimated relative risk (95% confidence interval) of colorectal cancer per 40 mg/mL higher fetuin-A concentrations (approximately one standard deviation) was 1.13 (1.02-1.24) overall, 1.21 (1.05-1.39) in men, 1.06 (0.93-1.22) in women, 1.13 (1.00-1.27) for colon cancer and 1.12 (0.94-1.32) for rectal cancer. To improve causal inference in a Mendelian Randomization approach, five tagging single nucleotide polymorphisms of the AHSG gene were genotyped in a subset of 456 case-control pairs. The AHSG allele-score explained 21% of the interindividual variation in plasma fetuin-A concentrations. In instrumental variable analysis, genetically raised fetuin-A was not associated with colorectal cancer risk (relative risk per 40 mg/mL genetically determined higher fetuin-A was 0.98, 95% confidence interval: 0.73-1.33). The findings of our study indicate a modest linear association between fetuin-A concentrations and risk of colorectal cancer but suggest that fetuin-A may not be causally related to colorectal cancer development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- fetuin-A
- AHSG
- colorectal cancer
- fetuin-A
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Nimptsch, Kathar ...
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Aleksandrova, Kr ...
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Boeing, Heiner
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Janke, Juergen
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Lee, Young-Ae
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Jenab, Mazda
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show more...
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Kong, So Yeon
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Tsilidis, Konsta ...
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Weiderpass, Elis ...
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Bueno-de-Mesquit ...
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Siersema, Peter ...
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Jansen, Eugene H ...
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Trichopoulou, An ...
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Tjonneland, Anne
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Olsen, Anja
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Wu, Chunsen
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Overvad, Kim
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Boutron-Ruault, ...
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Racine, Antoine
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Freisling, Heinz
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Katzke, Verena
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Kaaks, Rudolf
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Lagiou, Pagona
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Trichopoulos, Di ...
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Severi, Gianluca
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Naccarati, Aless ...
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Mattiello, Amali ...
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Palli, Domenico
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Grioni, Sara
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Tumino, Rosario
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Peeters, Petra H ...
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Ljuslinder, Ingr ...
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Nyström, Hanna
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Brändstedt, Jenn ...
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Sanchez, Maria-J ...
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Gurrea, Aurelio ...
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Bonet, Catalina ...
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Chirlaque, Maria ...
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Dorronsoro, Mire ...
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Quiros, Jose Ram ...
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Travis, Ruth C.
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Khaw, Kay-Tee
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Wareham, Nick
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Riboli, Elio
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Gunter, Marc J.
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Pischon, Tobias
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
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Lund University
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Umeå University
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Karolinska Institutet