Search: onr:"swepub:oai:lup.lub.lu.se:795a618c-eedc-4f33-b75c-5a8fa30c6fea" >
Plasma fetuin-A con...
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Nimptsch, Katharina
(author)
Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer
- Article/chapterEnglish2015
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LIBRIS-ID:oai:lup.lub.lu.se:795a618c-eedc-4f33-b75c-5a8fa30c6fea
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https://lup.lub.lu.se/record/7596602URI
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https://doi.org/10.1002/ijc.29448DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106308URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:131477306URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Fetuin-A, also referred to as alpha 2-Heremans-Schmid glycoprotein (AHSG), is a liver protein known to inhibit insulin actions. Hyperinsulinemia is a possible risk factor for colorectal cancer; however, the role of fetuin-A in the development of colorectal cancer is unclear. We investigated the association between circulating fetuin-A and colorectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. Fetuin-A concentrations were measured in prediagnostic plasma samples from 1,367 colorectal cancer cases and 1,367 matched controls. In conditional logistic regression models adjusted for potential confounders, the estimated relative risk (95% confidence interval) of colorectal cancer per 40 mg/mL higher fetuin-A concentrations (approximately one standard deviation) was 1.13 (1.02-1.24) overall, 1.21 (1.05-1.39) in men, 1.06 (0.93-1.22) in women, 1.13 (1.00-1.27) for colon cancer and 1.12 (0.94-1.32) for rectal cancer. To improve causal inference in a Mendelian Randomization approach, five tagging single nucleotide polymorphisms of the AHSG gene were genotyped in a subset of 456 case-control pairs. The AHSG allele-score explained 21% of the interindividual variation in plasma fetuin-A concentrations. In instrumental variable analysis, genetically raised fetuin-A was not associated with colorectal cancer risk (relative risk per 40 mg/mL genetically determined higher fetuin-A was 0.98, 95% confidence interval: 0.73-1.33). The findings of our study indicate a modest linear association between fetuin-A concentrations and risk of colorectal cancer but suggest that fetuin-A may not be causally related to colorectal cancer development.
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Aleksandrova, Krasimira
(author)
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Boeing, Heiner
(author)
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Janke, Juergen
(author)
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Lee, Young-Ae
(author)
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Jenab, Mazda
(author)
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Kong, So Yeon
(author)
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Tsilidis, Konstantinos K.
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Bueno-de-Mesquita, H. B(As)
(author)
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Siersema, Peter D.
(author)
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Jansen, Eugene H. J. M.
(author)
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Trichopoulou, Antonia
(author)
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Tjonneland, Anne
(author)
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Olsen, Anja
(author)
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Wu, Chunsen
(author)
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Overvad, Kim
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Racine, Antoine
(author)
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Freisling, Heinz
(author)
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Katzke, Verena
(author)
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Kaaks, Rudolf
(author)
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Lagiou, Pagona
(author)
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Trichopoulos, Dimitrios
(author)
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Severi, Gianluca
(author)
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Naccarati, Alessio
(author)
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Mattiello, Amalia
(author)
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Palli, Domenico
(author)
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Grioni, Sara
(author)
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Tumino, Rosario
(author)
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Peeters, Petra H.
(author)
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Ljuslinder, IngridUmeå universitet,Onkologi(Swepub:umu)inlj0001
(author)
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Nyström, HannaUmeå universitet,Institutionen för kirurgisk och perioperativ vetenskap(Swepub:umu)haanym01
(author)
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Brändstedt, JennyLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-jyb
(author)
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Sanchez, Maria-Jose
(author)
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Gurrea, Aurelio Barricarte
(author)
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Bonet, Catalina Bonet
(author)
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Chirlaque, Maria-Dolores
(author)
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Dorronsoro, Miren
(author)
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Quiros, Jose Ramon
(author)
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Travis, Ruth C.
(author)
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Khaw, Kay-Tee
(author)
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Wareham, Nick
(author)
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Riboli, Elio
(author)
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Gunter, Marc J.
(author)
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Pischon, Tobias
(author)
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Karolinska InstitutetOnkologi
(creator_code:org_t)
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In:International Journal of Cancer: Wiley137:4, s. 911-9200020-71361097-0215
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Nimptsch, Kathar ...
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Aleksandrova, Kr ...
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Boeing, Heiner
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Janke, Juergen
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Lee, Young-Ae
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Jenab, Mazda
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Kong, So Yeon
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Tsilidis, Konsta ...
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Weiderpass, Elis ...
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Bueno-de-Mesquit ...
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Siersema, Peter ...
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Jansen, Eugene H ...
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Trichopoulou, An ...
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Tjonneland, Anne
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Olsen, Anja
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Wu, Chunsen
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Overvad, Kim
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Boutron-Ruault, ...
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Racine, Antoine
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Freisling, Heinz
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Katzke, Verena
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Kaaks, Rudolf
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Lagiou, Pagona
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Trichopoulos, Di ...
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Severi, Gianluca
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Naccarati, Aless ...
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Mattiello, Amali ...
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Palli, Domenico
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Grioni, Sara
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Tumino, Rosario
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Peeters, Petra H ...
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Ljuslinder, Ingr ...
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Nyström, Hanna
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Sanchez, Maria-J ...
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Bonet, Catalina ...
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Chirlaque, Maria ...
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Dorronsoro, Mire ...
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Quiros, Jose Ram ...
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Travis, Ruth C.
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Khaw, Kay-Tee
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Wareham, Nick
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Gunter, Marc J.
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