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A large multicentre...
A large multicentre analysis of CTGF - 2945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype
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Rueda, B. (author)
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Simeon, C. (author)
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- Hesselstrand, Roger (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Herrick, A. (author)
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Worthington, J. (author)
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Ortego-Centeno, N. (author)
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Riemekasten, G. (author)
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Fonollosa, V. (author)
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Vonk, M. C. (author)
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van den Hoogen, F. H. J. (author)
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Sanchez-Roman, J. (author)
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Aguirre-Zamorano, M. A. (author)
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Garcia-Portales, R. (author)
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Pros, A. (author)
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Camps, M. T. (author)
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Gonzalez-Gay, M. A. (author)
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Gonzalez-Escribano, M. F. (author)
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Coenen, M. J. (author)
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Lambert, N. (author)
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Nelson, J. L. (author)
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Radstake, T. R. D. J. (author)
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Martin, J. (author)
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(creator_code:org_t)
- 2008-12-03
- 2009
- English.
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In: Annals of the Rheumatic Diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 68:10, s. 1618-1620
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Abstract
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- Objective: To conduct a replication study to investigate whether the 2945 CTGF genetic variant is associated with systemic sclerosis (SSc) susceptibility or specific SSc phenotype. Methods: The study population comprised 1180 patients with SSc and 1784 healthy controls from seven independent case-control sets of European ancestry (Spanish, French, Dutch, German, British, Swedish and North American). The 2945 CTGF genetic variant was genotyped using a Taqman 59 allelic discrimination assay. Results: An independent association study showed in all the case-control cohorts no association of the CTGF 2945 polymorphism with SSc susceptibility. These findings were confirmed by a meta-analysis giving a pooled OR=1.12 (95% CI 0.99 to 1.25), p=0.06. Investigation of the possible contribution of the 2945 CTGF genetic variant to SSc phenotype showed that stratification according to SSc subtypes (limited or diffuse), selective autoantibodies (anti-topoisomerase I or anticentromere) or pulmonary involvement reached no statistically significant skewing. Conclusion: The results do not confirm previous findings and suggest that the CTGF 2945 promoter polymorphism does not play a major role in SSc susceptibility or clinical phenotype.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Rueda, B.
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Simeon, C.
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Hesselstrand, Ro ...
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Herrick, A.
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Worthington, J.
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Ortego-Centeno, ...
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show more...
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Riemekasten, G.
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Fonollosa, V.
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Vonk, M. C.
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van den Hoogen, ...
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Sanchez-Roman, J ...
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Aguirre-Zamorano ...
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Garcia-Portales, ...
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Pros, A.
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Camps, M. T.
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Gonzalez-Gay, M. ...
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Gonzalez-Escriba ...
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Coenen, M. J.
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Lambert, N.
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Nelson, J. L.
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Radstake, T. R. ...
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Martin, J.
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Annals of the Rh ...
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Lund University