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Behavioral and Psyc...
Behavioral and Psychological Symptoms of Dementia in Different Dementia Disorders : A Large-Scale Study of 10,000 Individuals
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- Schwertner, Emilia (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden
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- Pereira, Joana B. (author)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Karolinska Inst, Sweden; Lund Univ, Sweden
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- Xu, Hong (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden
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- Secnik, Juraj (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden
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- Winblad, Bengt (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Eriksdotter, Maria (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Nägga, Katarina (author)
- Linköpings universitet,Linköping University,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Medicinska och geriatriska akutkliniken,Lund Univ, Sweden
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- Religa, Dorota (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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(creator_code:org_t)
- IOS PRESS, 2022
- 2022
- English 12 s.
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In: Journal of Alzheimer's Disease. - : IOS PRESS. - 1387-2877 .- 1875-8908. ; 87:3, s. 1307-1318
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Abstract
Subject headings
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- Background: The majority of individuals with dementia will suffer from behavioral and psychological symptoms of dementia (BPSD). These symptoms contribute to functional impairment and caregiver burden. Objective: To characterize BPSD in Alzheimer's disease (AD), vascular dementia (VaD), mixed (Mixed) dementia, Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and unspecified dementia in individuals residing in long-term care facilities. Methods: We included 10,405 individuals with dementia living in long-term care facilities from the Swedish registry for cognitive/dementia disorders (SveDem) and the Swedish BPSD registry. BPSD was assessed with the Neuropsychiatric Inventory - Nursing Home Version (NPI-NH). Multivariate logistic regression models were used to evaluate the associations between dementia diagnoses and different BPSDs. Results: The most common symptoms were aberrant motor behavior, agitation, and irritability. Compared to AD, we found a lower risk of delusions (in FTD, unspecified dementia), hallucinations (FTD), agitation (VaD, PDD, unspecified dementia), elation/euphoria (DLB), anxiety (Mixed, VaD, unspecified dementia), disinhibition (in PDD), irritability (in DLB, FTD, unspecified dementia), aberrant motor behavior (Mixed, VaD, unspecified dementia), and sleep and night-time behavior changes (unspecified dementia). Higher risk of delusions (DLB), hallucinations (DLB, PDD), apathy (VaD, FTD), disinhibition (FTD), and appetite and eating abnormalities (FTD) were also found in comparison to AD. Conclusion: Although individuals in our sample were diagnosed with different dementia disorders, they all exhibited aberrant motor behavior, agitation, and irritability. This suggests common underlying psychosocial or biological mechanisms. We recommend prioritizing these symptoms while planning interventions in long-term care facilities.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- Aberrant motor behavior
- aging
- agitation
- Alzheimer's disease
- behavioral and psychological symptoms of dementia
- behavioral problem
- dementia
- irritability
- Neuropsychiatric Inventory
- nursing homes
- Aberrant motor behavior; aging; agitation; Alzheimers disease; behavioral problem; behavioral and psychological symptoms of dementia; dementia; irritability; Neuropsychiatric Inventory; nursing homes
Publication and Content Type
- art (subject category)
- ref (subject category)
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