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Tumor necrosis fact...
Tumor necrosis factor-alpha does not mediate diabetes-induced vascular inflammation in mice.
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- Öhman, Jenny (author)
- Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Vascular Physiology,Lund University Research Groups,Cardiovascular Research - Immunity and Atherosclerosis
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- Nordin Fredrikson, Gunilla (author)
- Malmö högskola,Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Fakulteten för hälsa och samhälle (HS)
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- Berglund, Lisa (author)
- Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Vascular Physiology,Lund University Research Groups,Cardiovascular Research - Immunity and Atherosclerosis
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- Gustavsson, Carin (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Bengtsson, Eva (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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- Smith, Maj-Lis (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Agardh, Carl-David (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Agardh, Elisabet (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Jovinge, Stefan (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Gomez, Maria (author)
- Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Vascular Physiology,Lund University Research Groups,Cardiovascular Research - Immunity and Atherosclerosis
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Arteriosclerosis, Thrombosis and Vascular Biology. - 1524-4636 .- 1079-5642. ; 29:10, s. 1465-1470
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- OBJECTIVE: Vascular inflammation is a key feature of both micro- and macrovascular complications in diabetes. Several lines of evidence have implicated the cytokine tumor necrosis factor (TNF) alpha as an important mediator of inflammation in diabetes. In the present study we evaluated the role of TNF alpha in streptozotocin (STZ)-induced diabetes on vascular inflammation in C57BL/6 wild-type and apoE-/- mice. METHODS AND RESULTS: Diabetes increased the expression of vascular cell adhesion molecule (VCAM)-1 in cerebral arteries 150 m in diameter as well as the macrophage accumulation in aortic root atherosclerotic plaques in apoE-/- mice. A more pronounced vascular inflammatory response was observed in diabetic TNF alpha-deficient apoE-/- mice. These mice were also characterized by increased accumulation of IgG and IgM autoantibodies in atherosclerotic lesions. Diabetes also increased VCAM-1 expression and plaque formation in apoE-competent TNF alpha -/- mice, whereas no such effects were observed in C57BL/6 wild-type mice. CONCLUSIONS: The present findings suggest that TNF alpha does not mediate diabetic-induced vascular inflammation in mice and reveal an unexpected protective role for TNF alpha. These effects are partly attributable to a direct antiinflammatory role of TNF alpha, but may also reflect a defective development of the immune system in these mice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Lipoproteins
- Inflammation: etiology
- Diabetic Angiopathies: etiology
- Experimental: complications
- Diabetes Mellitus
- Cerebral Arteries: chemistry
- Blood Glucose: analysis
- Autoantibodies: analysis
- Apolipoproteins E: physiology
- Atherosclerosis: etiology
- Vascular Cell Adhesion Molecule-1: blood
- LDL: immunology
- Tumor Necrosis Factor-alpha: physiology
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Öhman, Jenny
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Nordin Fredrikso ...
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Berglund, Lisa
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Gustavsson, Cari ...
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Bengtsson, Eva
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Smith, Maj-Lis
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show more...
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Agardh, Carl-Dav ...
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Agardh, Elisabet
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Jovinge, Stefan
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Gomez, Maria
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Nilsson, Jan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Arteriosclerosis ...
- By the university
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Lund University
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Malmö University