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- Kleef, RalfDr. Kleef hyperthermie (author)
Complete Clinical Remission of Stage IV Triple-Negative Breast Cancer Lung Metastasis Administering Low-Dose Immune Checkpoint Blockade in Combination With Hyperthermia and Interleukin-2
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2018-09-07
- SAGE Publications,2018
- 7 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:7b2b5422-14a1-433e-b133-713a1dbd3aac
- https://lup.lub.lu.se/record/7b2b5422-14a1-433e-b133-713a1dbd3aacURI
- https://doi.org/10.1177/1534735418794867DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- The prognosis of triple-negative breast cancer with metastases after chemotherapy remains dismal. We report the case of a 50-year-old female with first disease recurrence at the axillary lymph node and, later on, bilateral pulmonary metastases with severe shortness of breath. The patient received low-dose immune checkpoint blockade (concurrent nivolumab and ipilimumab) weekly over 3 weeks with regional hyperthermia 3 times a week, followed by systemic fever-range hyperthermia induced by interleukin-2 for 5 days. She went into complete remission of her pulmonary metastases with transient WHO I-II diarrhea and skin rash. The patient remained alive for 27 months after the start of treatment, with recurrence of metastases as a sternal mass, and up to 3 cm pleural metastases. This exceptional response should instigate further research efforts with this protocol, which consists only of approved drugs and treatments.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- checkpoint inhibition
- hyperthermia
- IL-2
- immunotherapy
- TNBC
Added entries (persons, corporate bodies, meetings, titles ...)
- Moss, RalphCancer Decisions, Lermont (author)
- Szasz, A. MarcellLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Semmelweis University(Swepub:lu)ma4462sz (author)
- Bohdjalian, ArthurRudolfinerhaus, Vienna (author)
- Bojar, HansNextGen Oncology Group, Düsseldorf (author)
- Bakacs, TiborPRET Therapeutics Ltd, Budapest (author)
- Dr. Kleef hyperthermieCancer Decisions, Lermont (creator_code:org_t)
Related titles
- In:Integrative Cancer Therapies: SAGE Publications17:4, s. 1297-13031534-73541552-695X
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