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Atrial fibrillatory...
Atrial fibrillatory rate as predictor of recurrence of atrial fibrillation in horses treated medically or with electrical cardioversion
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- Buhl, Rikke (author)
- University of Copenhagen
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- Hesselkilde, Eva M. (author)
- University of Copenhagen
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- Carstensen, Helena (author)
- University of Copenhagen
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- Hopster-Iversen, Charlotte (author)
- University of Copenhagen
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- van Loon, Gunther (author)
- Ghent University
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- Decloedt, Annelies (author)
- Ghent University
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- Van Steenkiste, Glenn (author)
- Ghent University
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Marr, Celia M (author)
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Reef, Virginia B. (author)
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- Schwarzwald, Colin C. (author)
- University of Zurich
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- Mitchell, Katharyn J. (author)
- University of Zurich
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- Nostell, Katarina (author)
- Sveriges lantbruksuniversitet,Swedish University of Agricultural Sciences,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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Nogradi, Nora (author)
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- Nielsen, Søren S. (author)
- University of Copenhagen
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- Carlson, Jonas (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Platonov, Pyotr G (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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(creator_code:org_t)
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- 2022-01-13
- 2022
- English.
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In: Equine Veterinary Journal. - : Wiley. - 0425-1644 .- 2042-3306. ; 54:6, s. 1013-1022
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Abstract
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- Background: The recurrence rate of atrial fibrillation (AF) in horses after cardioversion to sinus rhythm (SR) is relatively high. Atrial fibrillatory rate (AFR) derived from surface ECG is considered a biomarker for electrical remodelling and could potentially be used for the prediction of successful AF cardioversion and AF recurrence. Objectives: Evaluate if AFR was associated with successful treatment and could predict AF recurrence in horses. Study design: Retrospective multicentre study. Methods: Electrocardiograms (ECG) from horses with persistent AF admitted for cardioversion with either medical treatment (quinidine) or transvenous electrical cardioversion (TVEC) were included. Bipolar surface ECG recordings were analysed by spatiotemporal cancellation of QRST complexes and calculation of AFR from the remaining atrial signal. Kaplan-Meier survival curve and Cox regression analyses were performed to assess the relationship between AFR and the risk of AF recurrence. Results: Of the 195 horses included, 74 received quinidine treatment and 121 were treated with TVEC. Ten horses did not cardiovert to SR after quinidine treatment and AFR was higher in these, compared with the horses that successfully cardioverted to SR (median [interquartile range]), (383 [367-422] vs 351 [332-389] fibrillations per minute (fpm), P <.01). Within the first 180 days following AF cardioversion, 12% of the quinidine and 34% of TVEC horses had AF recurrence. For the horses successfully cardioverted with TVEC, AFR above 380 fpm was significantly associated with AF recurrence (hazard ratio = 2.4, 95% confidence interval 1.2-4.8, P =.01). Main limitations: The treatment groups were different and not randomly allocated, therefore the two treatments cannot be compared. Medical records and the follow-up strategy varied between the centres. Conclusions: High AFR is associated with failure of quinidine cardioversion and AF recurrence after successful TVEC. As a noninvasive marker that can be retrieved from surface ECG, AFR can be clinically useful in predicting the probability of responding to quinidine treatment as well as maintaining SR after electrical cardioversion.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Klinisk vetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Clinical Science (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Buhl, Rikke
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Hesselkilde, Eva ...
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Carstensen, Hele ...
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Hopster-Iversen, ...
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van Loon, Gunthe ...
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Decloedt, Anneli ...
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show more...
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Van Steenkiste, ...
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Marr, Celia M
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Reef, Virginia B ...
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Schwarzwald, Col ...
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Mitchell, Kathar ...
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Nostell, Katarin ...
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Nogradi, Nora
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Nielsen, Søren S ...
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Carlson, Jonas
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Platonov, Pyotr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Veterinary Scien ...
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and Clinical Science
- Articles in the publication
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Equine Veterinar ...
- By the university
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Lund University
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Swedish University of Agricultural Sciences