Pathophysiology of L-DOPA-Induced Dyskinesia in Parkinson's Disease

• This chapter begins with a discussion of motor complications of L-DOPA pharmacotherapy. It then discusses animal models of treatment-induced motor complications and the multilayered pathophysiology of L-DOPA-induced dyskinesia, presynaptic changes in DA release and clearance, imbalance in the activity of striatal efferent pathways, altered plasticity of corticostriatal synapses, altered activity in peptidergic and GABAergic pathways to the basal ganglia output nuclei, and system-level changes in cortico-basal ganglionic circuits.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Publication and Content Type

kap (subject category)

ref (subject category)