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Intake of B vitamin...
Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study
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- Hakola, Leena (author)
- University of Tampere
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- Mramba, Lazarus K (author)
- University of South Florida
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- Uusitalo, Ulla (author)
- University of South Florida
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- Andrén Aronsson, Carin (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Hummel, Sandra (author)
- Technical University of Munich
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- Niinistö, Sari (author)
- Finnish National Institute for Health and Welfare
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- Erlund, Iris (author)
- Finnish National Institute for Health and Welfare
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- Yang, Jimin (author)
- University of South Florida
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- Rewers, Marian J (author)
- University of Colorado-Denver
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- McIndoe, Richard A (author)
- Medical College of Georgia
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- Rich, Stephen S (author)
- University of Virginia
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- Hagopian, William A (author)
- Pacific Northwest Research Institute
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- Ziegler, Anette (author)
- Technical University of Munich
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Toppari, Jorma (author)
- Turku University Hospital
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- Krischer, Jeffrey P (author)
- University of South Florida
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- Norris, Jill M (author)
- University of Colorado at Denver Anschutz Medical Campus
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- Virtanen, Suvi M (author)
- University of Tampere
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(creator_code:org_t)
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- English.
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In: European Journal of Nutrition. - 1436-6215.
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Abstract
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- PURPOSE: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years.METHODS: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country.RESULTS: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes "any IA" and progression from IA to T1D. CONCLUSION: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Hakola, Leena
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Mramba, Lazarus ...
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Uusitalo, Ulla
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Andrén Aronsson, ...
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Hummel, Sandra
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Niinistö, Sari
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show more...
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Erlund, Iris
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Yang, Jimin
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Rewers, Marian J
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Akolkar, Beena
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McIndoe, Richard ...
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Rich, Stephen S
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Hagopian, Willia ...
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Ziegler, Anette
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Lernmark, Åke
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Toppari, Jorma
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Krischer, Jeffre ...
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Norris, Jill M
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Virtanen, Suvi M
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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European Journal ...
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Lund University