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Nuclear microscopy:...
Nuclear microscopy: A tool for and percutaneous absorption imaging elemental distribution in vivo
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Verissimo, Ana (author)
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Alves, Luis C. (author)
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Filipe, Paulo (author)
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Silva, Joao N. (author)
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Silva, Raquel (author)
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Ynsa, Maria Dolores (author)
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Gontier, Etienne (author)
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Moretto, Philippe (author)
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- Pallon, Jan (author)
- Lund University,Lunds universitet,Kärnfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Nuclear physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH
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Pinheiro, Teresa (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Microscopy Research and Technique. - : Wiley. - 1059-910X .- 1097-0029. ; 70:4, s. 302-309
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http://dx.doi.org/10...
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Abstract
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- Nuclear microscopy is a technique based on a focused beam of accelerated particles that has the ability of imaging the morphology of the tissue in vivo and of producing the correspondent elemental maps, whether in major, minor, or trace concentrations. These characteristics constitute a strong advantage in studying the morphology of human skin, its elemental distributions and the permeation mechanisms of chemical compounds. In this study, nuclear microscopy techniques such as scanning transmission ion microscopy and particle induced X-ray emission were applied simultaneously, to cryopreserved human skin samples with the purpose of obtaining high-resolution images of cells and tissue morphology. In addition, quantitative elemental profiling and mapping of phosphorus, calcium, chlorine, and potassium in skin cross-sections were obtained. This procedure accurately distinguishes the epidermal strata and dermis by overlapping in real time the elemental information with density images obtained from the transmitted beam. A validation procedure for elemental distributions in human skin based on differential density of epidermal strata and dermis was established. As demonstrated, this procedure can be used in future studies as a tool for the in vivo examination of trans-epidermal and -dermal delivery of products. .
Subject headings
- NATURVETENSKAP -- Fysik -- Subatomär fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Subatomic Physics (hsv//eng)
Keyword
- human skin
- X-ray microscopy
- PIXE
- STIM
- metals
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Verissimo, Ana
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Alves, Luis C.
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Filipe, Paulo
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Silva, Joao N.
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Silva, Raquel
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Ynsa, Maria Dolo ...
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show more...
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Gontier, Etienne
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Moretto, Philipp ...
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Pallon, Jan
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Pinheiro, Teresa
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Subatomic Physic ...
- Articles in the publication
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Microscopy Resea ...
- By the university
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Lund University