onr:"swepub:oai:lup.lub.lu.se:7dfdf7ef-b5b6-4f47-8690-eb1aa2f46ed6"
Search: onr:"swepub:oai:lup.lub.lu.se:7dfdf7ef-b5b6-4f47-8690-eb1aa2f46ed6" > TRIM28 Controls a G...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Brattås, Per LudvikLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups (author)
TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- Elsevier BV,2017
- 11 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:7dfdf7ef-b5b6-4f47-8690-eb1aa2f46ed6
- https://lup.lub.lu.se/record/7dfdf7ef-b5b6-4f47-8690-eb1aa2f46ed6URI
- https://doi.org/10.1016/j.celrep.2016.12.010DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:135304254URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311976URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- NATURVETENSKAP Biologi Genetik hsv//swe
- NATURAL SCIENCES Biological Sciences Genetics hsv//eng
- NATURVETENSKAP Biologi Evolutionsbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Evolutionary Biology hsv//eng
- epigenetics
- gene regulation
- human development
- neural stem cells
- transposable elements
Added entries (persons, corporate bodies, meetings, titles ...)
- Jönsson, Marie E.Lund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups(Swepub:lu)mphy-mjo (author)
- Fasching, LianaLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups(Swepub:lu)med-lfi (author)
- Nelander Wahlestedt, JennyLund University,Lunds universitet,Regeneration in Movement Disorders,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-jnr (author)
- Shahsavani, MansourehKarolinska Institutet,Karolinska Institute (author)
- Falk, RonnyKarolinska Institute (author)
- Falk, Anna HelenaKarolinska Institutet,Karolinska Institute(Swepub:lu)an1083fa (author)
- Jern, PatricUppsala universitet,Uppsala University,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)patrjern (author)
- Parmar, MalinLund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups(Swepub:lu)mphy-mpa (author)
- Jakobsson, JohanLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups(Swepub:lu)mphy-jja (author)
- Molekylär neurogenetikForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Cell Reports: Elsevier BV18:1, s. 1-112211-1247
Internet link
- http://dx.doi.org/10.1016/j.celrep.2016.12.010FULLTEXT
- http://www.cell.com/article/S2211124716316837/pdf
- https://uu.diva-portal.org/smash/get/diva2:1061971/FULLTEXT01.pdffulltext:print
- https://lup.lub.lu.se/record/7dfdf7ef-b5b6-4f47-8690-eb1aa2f46ed6
- https://doi.org/10.1016/j.celrep.2016.12.010
- http://kipublications.ki.se/Default.aspx?queryparsed=id:135304254
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311976
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Brattås, Per Lud ...
- Jönsson, Marie E ...
- Fasching, Liana
- Nelander Wahlest ...
- Shahsavani, Mans ...
- Falk, Ronny
- show more...
- Falk, Anna Helen ...
- Jern, Patric
- Parmar, Malin
- Jakobsson, Johan
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Genetics
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Evolutionary Bio ...
- Articles in the publication
- Cell Reports
- By the university
- Lund University
- Karolinska Institutet
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
