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NT-proBNP on Cobas ...
NT-proBNP on Cobas h 232 in point-of-care testing: Performance in the primary health care versus in the hospital laboratory
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-08-11
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Informa UK Limited,2015
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LIBRIS-ID:oai:lup.lub.lu.se:7e43632c-1c3c-4c16-8c6a-acff7ef6482e
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https://lup.lub.lu.se/record/8074253URI
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https://doi.org/10.3109/00365513.2015.1066846DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Background. NT-proBNP may be useful for ruling out heart failure in primary health care. In this study we examined the analytical quality of NT-proBNP in primary health care on the Cobas h 232 point-of-care instrument compared with measurements performed in a hospital laboratory. Materials and methods. Blood samples requested for NT-proBNP were collected in primary health care (n = 95) and in a hospital laboratory (n = 107). NT-proBNP was measured on-site on Cobas h 232 instruments both in primary health care centres and at the hospital laboratory and all samples were also analyzed with a comparison method at the hospital. Precision, trueness, accuracy, and lot-variation were determined at different concentration levels and evaluated according to acceptance criteria. Furthermore user-friendliness was assessed by questionnaires. Results. For Cobas h 232 repeatability CV was 8.5-10.7% in the hospital setting and 5.3-10.0% in the primary health care and within the analytical quality specifications, but higher than with the comparison method (<4%). NT-proBNP results obtained in primary health care were significantly higher than by the hospital comparison method (bias ranged from 14.3-23.7%), whereas there was no significant bias when Cobas h 232 was used in the hospital setting (bias ranged from 4.9 to 7.0%). User-friendliness of Cobas h 232 was overall acceptable. Conclusion. Cobas h 232 point-of-care instrument for measurement of NT-proBNP performed satisfactorily with regard to precision, user-friendliness, and lot-variation. A decrease in NT-proBNP levels observed in samples transported to a central laboratory needs further attention and investigation.
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Ramanathan, Ramshanker
(author)
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Breindahl, Torben
(author)
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Brokner, Mette
(author)
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Christiansen, Anne L.
(author)
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Eng, Oyvin
(author)
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Hammer, Ida J.
(author)
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Herrera, Catherine B.
(author)
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Jansen, Aina
(author)
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Langsjoen, Eva C.
(author)
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Lokkebo, Elisabeth S.
(author)
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Osestad, Toril
(author)
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Schroder, Anne D.
(author)
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Walther, LisaLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)klke-lm0
(author)
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Avdelningen för klinisk kemi och farmakologiInstitutionen för laboratoriemedicin
(creator_code:org_t)
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In:Scandinavian Journal of Clinical & Laboratory Investigation: Informa UK Limited75:7, s. 602-6091502-76860036-5513
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Gils, Charlotte
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Ramanathan, Rams ...
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Breindahl, Torbe ...
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Brokner, Mette
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Eng, Oyvin
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Hammer, Ida J.
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Herrera, Catheri ...
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Jansen, Aina
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Langsjoen, Eva C ...
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Lokkebo, Elisabe ...
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Osestad, Toril
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Schroder, Anne D ...
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Walther, Lisa
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Lund University