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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05071naa a2200673 4500 | |
| 001 | oai:lup.lub.lu.se:7efe5bbf-0ff7-4f5a-894b-0299ccb2dff7 | |
| 003 | SwePub | |
| 008 | 161207s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/7efe5bbf-0ff7-4f5a-894b-0299ccb2dff72 URI |
| 024 | 7 | a https://doi.org/10.1038/bcj.2016.1032 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a De Stefano, V.u Catholic University of the Sacred Heart, Rome4 aut |
| 245 | 1 0 | a Splanchnic vein thrombosis in myeloproliferative neoplasms : Risk factors for recurrences in a cohort of 181 patients |
| 264 | c 2016-11-04 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2016 |
| 520 | a We retrospectively studied 181 patients with polycythaemia vera (n=67), essential thrombocythaemia (n=67) or primary myelofibrosis (n=47), who presented a first episode of splanchnic vein thrombosis (SVT). Budd-Chiari syndrome (BCS) and portal vein thrombosis were diagnosed in 31 (17.1%) and 109 (60.3%) patients, respectively; isolated thrombosis of the mesenteric or splenic veins was detected in 18 and 23 cases, respectively. After this index event, the patients were followed for 735 patient years (pt-years) and experienced 31 recurrences corresponding to an incidence rate of 4.2 per 100 pt-years. Factors associated with a significantly higher risk of recurrence were BCS (hazard ratio (HR): 3.03), history of previous thrombosis (HR: 3.62), splenomegaly (HR: 2.66) and leukocytosis (HR: 2.8). Vitamin K-antagonists (VKA) were prescribed in 85% of patients and the recurrence rate was 3.9 per 100 pt-years, whereas in the small fraction (15%) not receiving VKA more recurrences (7.2 per 100 pt-years) were reported. Intracranial and extracranial major bleeding was recorded mainly in patients on VKA and the corresponding rate was 2.0 per 100 pt-years. In conclusion, despite anticoagulation treatment, the recurrence rate after SVT in myeloproliferative neoplasms is high and suggests the exploration of new avenues of secondary prophylaxis with new antithrombotic drugs and JAK-2 inhibitors. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
| 700 | 1 | a Vannucchi, A. M.u University of Florence4 aut |
| 700 | 1 | a Ruggeri, M.u Ospedale San Bortolo4 aut |
| 700 | 1 | a Cervantes, F.u Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)4 aut |
| 700 | 1 | a Alvarez-Larrán, A.u Hospital del Mar Medical Research Institute4 aut |
| 700 | 1 | a Iurlo, A.u Maggiore Hospital Policlinico4 aut |
| 700 | 1 | a Randi, M. L.u University of Padova4 aut |
| 700 | 1 | a Pieri, L.u University of Florence4 aut |
| 700 | 1 | a Rossi, E.u Catholic University of the Sacred Heart, Rome4 aut |
| 700 | 1 | a Guglielmelli, P.u University of Florence4 aut |
| 700 | 1 | a Betti, S.u Catholic University of the Sacred Heart, Rome4 aut |
| 700 | 1 | a Elli, E.u University of Milano-Bicocca4 aut |
| 700 | 1 | a Finazzi, M. C.u Papa Giovanni XXIII Hospital4 aut |
| 700 | 1 | a Finazzi, G.u Papa Giovanni XXIII Hospital4 aut |
| 700 | 1 | a Zetterberg, E.u Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-ezt |
| 700 | 1 | a Vianelli, N.u St. Orsola-Malpighi University Hospital4 aut |
| 700 | 1 | a Gaidano, G.u University of Eastern Piedmont4 aut |
| 700 | 1 | a Nichele, I.u Ospedale San Bortolo4 aut |
| 700 | 1 | a Cattaneo, D.u Maggiore Hospital Policlinico4 aut |
| 700 | 1 | a Palova, M.u University Hospital of Olomouc4 aut |
| 700 | 1 | a Ellis, M. H.u Meir Medical Center4 aut |
| 700 | 1 | a Cacciola, E.u University of Catania4 aut |
| 700 | 1 | a Tieghi, A.u Arcispedale Santa Maria Nuova4 aut |
| 700 | 1 | a Hernandez-Boluda, J. C.u University and Polytechnic Hospital la Fe4 aut |
| 700 | 1 | a Pungolino, E.u Niguarda Hospital4 aut |
| 700 | 1 | a Specchia, G.u Bari University Hospital4 aut |
| 700 | 1 | a Rapezzi, D.u A.O. Santa Croce e Carle4 aut |
| 700 | 1 | a Forcina, A.u San Raffaele Scientific Institute4 aut |
| 700 | 1 | a Musolino, C.u Bari University Hospital4 aut |
| 700 | 1 | a Carobbio, A.u Papa Giovanni XXIII Hospital4 aut |
| 700 | 1 | a Griesshammer, M.u Ruhr-University Bochum4 aut |
| 700 | 1 | a Barbui, T.u Papa Giovanni XXIII Hospital4 aut |
| 710 | 2 | a Catholic University of the Sacred Heart, Romeb University of Florence4 org |
| 773 | 0 | t Blood Cancer Journald : Springer Science and Business Media LLCg 6:11q 6:11x 2044-5385 |
| 856 | 4 | u http://dx.doi.org/10.1038/bcj.2016.103x freey FULLTEXT |
| 856 | 4 | u https://www.nature.com/articles/bcj2016103.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/7efe5bbf-0ff7-4f5a-894b-0299ccb2dff7 |
| 856 | 4 8 | u https://doi.org/10.1038/bcj.2016.103 |
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