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- Aqueveque, Pedro (author)
Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- 2015-05-28
- Walter de Gruyter GmbH,2015
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:7efeefa6-e900-4947-882d-964899c0f21d
- https://lup.lub.lu.se/record/7975614URI
- https://doi.org/10.1515/znc-2015-5005DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.
Subject headings and genre
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- antibacterial activity
- MIC
- MS-3
- Stereum rameale
- vibralactone
Added entries (persons, corporate bodies, meetings, titles ...)
- Leonardo Cespedes, Carlos (author)
- Becerra, Jose (author)
- Davila, Marcelo (author)
- Sterner, OlovLund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ok2-ost (author)
- Centrum för analys och syntesKemiska institutionen (creator_code:org_t)
Related titles
- In:Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences: Walter de Gruyter GmbH70:3-4, s. 97-1020939-5075
- In:Zeitschrift für Naturforschung C: Walter de Gruyter GmbH70:3-4, s. 97-1021865-7125
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