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Healthy lifestyle a...
Healthy lifestyle and the risk of pancreatic cancer in the EPIC study
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- Naudin, Sabine (author)
- International Agency for Research on Cancer, World Health Organization
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- Viallon, Vivian (author)
- International Agency for Research on Cancer, World Health Organization
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- Hashim, Dana (author)
- Icahn School of Medicine at Mount Sinai
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- Freisling, Heinz (author)
- International Agency for Research on Cancer, World Health Organization
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- Jenab, Mazda (author)
- International Agency for Research on Cancer, World Health Organization
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization
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- Perrier, Flavie (author)
- International Agency for Research on Cancer, World Health Organization
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- McKenzie, Fiona (author)
- International Agency for Research on Cancer, World Health Organization
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- Bueno-de-Mesquita, H. Bas (author)
- National Institute for Public Health and the Environment (RIVM),Imperial College London,University Medical Center Utrecht
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- Olsen, Anja (author)
- Danish Cancer Society
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- Tjønneland, Anne (author)
- University of Copenhagen,Danish Cancer Society
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- Dahm, Christina C. (author)
- Aarhus University
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- Overvad, Kim (author)
- Aalborg University,Aarhus University
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- Mancini, Francesca R. (author)
- Institut Gustave Roussy
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- Rebours, Vinciane (author)
- Beaujon Hospital,Paris Diderot University
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- Boutron-Ruault, Marie Christine (author)
- Institut Gustave Roussy
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- Katzke, Verena (author)
- German Cancer Research Centre
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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- Bergmann, Manuela (author)
- German Institute of Human Nutrition
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- Boeing, Heiner (author)
- German Institute of Human Nutrition
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- Peppa, Eleni (author)
- Hellenic Health Foundation, Athens
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- Karakatsani, Anna (author)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Trichopoulou, Antonia (author)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Pala, Valeria (author)
- Istituto Nazionale dei Tumori
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- Masala, Giovana (author)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Panico, Salvatore (author)
- University of Naples Federico II
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- Tumino, Rosario (author)
- Civic and M.P Arezzo Hospital
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- Sacerdote, Carlotta (author)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- May, Anne M. (author)
- University Medical Center Utrecht
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- van Gils, Carla H. (author)
- University Medical Center Utrecht
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- Rylander, Charlotta (author)
- UiT The Arctic University of Norway, Tromsø
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- Borch, Kristin Benjaminsen (author)
- UiT The Arctic University of Norway, Tromsø
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- Chirlaque López, María Dolores (author)
- University of Murcia
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- Sánchez, Maria Jose (author)
- University of Granada
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- Ardanaz, Eva (author)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP),Navarre Public Health Institute (ISPN)
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- Quirós, José Ramón (author)
- Public Health Directorate
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Amiano Exezarreta, Pilar (author)
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- Sund, Malin (author)
- Umeå universitet,Umeå University,Kirurgi
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- Drake, Isabel (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Regnér, Sara (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Travis, Ruth C. (author)
- University of Oxford
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- Wareham, Nick (author)
- University of Cambridge
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- Aune, Dagfinn (author)
- Oslo university hospital,Bjørknes University College,Imperial College London
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- Riboli, Elio (author)
- Imperial College London
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- Gunter, Marc J. (author)
- International Agency for Research on Cancer, World Health Organization
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- Duell, Eric J. (author)
- Catalan Institute of Oncology
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- Brennan, Paul (author)
- International Agency for Research on Cancer, World Health Organization
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- Ferrari, Pietro (author)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2019-09-28
- 2020
- English 12 s.
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In: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 35:10, s. 975-986
- Related links:
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http://dx.doi.org/10...
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https://munin.uit.no...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) were diagnosed from 400,577 participants followed-up for 15 years (median). HLI scores combined smoking, alcohol intake, dietary exposure, physical activity and, in turn, overall and central adiposity using BMI (HLIBMI) and waist-to-hip ratio (WHR, HLIWHR), respectively. High values of HLI indicate adherence to healthy behaviors. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and 95% confidence intervals (CI). Sensitivity analyses were performed by excluding, in turn, each factor from the HLI score. Population attributable fractions (PAF) were estimated assuming participants’ shift to healthier lifestyles. The HRs for a one-standard deviation increment of HLIBMI and HLIWHR were 0.84 (95% CI: 0.79, 0.89; ptrend = 4.3e−09) and 0.77 (0.72, 0.82; ptrend = 1.7e−15), respectively. Exclusions of smoking from HLIWHR resulted in HRs of 0.88 (0.82, 0.94; ptrend = 4.9e−04). The overall PAF estimate was 19% (95% CI: 11%, 26%), and 14% (6%, 21%) when smoking was removed from the score. Adherence to a healthy lifestyle was inversely associated with PC risk, beyond the beneficial role of smoking avoidance. Public health measures targeting compliance with healthy lifestyles may have an impact on PC incidence.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- EPIC
- Healthy Lifestyle Index
- Pancreatic cancer
- Population attributable fraction
- Prospective study
- Pancreatic cancer
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Naudin, Sabine
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Viallon, Vivian
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Hashim, Dana
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Freisling, Heinz
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Jenab, Mazda
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Weiderpass, Elis ...
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show more...
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Perrier, Flavie
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McKenzie, Fiona
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Bueno-de-Mesquit ...
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Olsen, Anja
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Tjønneland, Anne
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Dahm, Christina ...
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Overvad, Kim
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Mancini, Frances ...
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Rebours, Vincian ...
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Boutron-Ruault, ...
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Katzke, Verena
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Kaaks, Rudolf
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Bergmann, Manuel ...
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Boeing, Heiner
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Peppa, Eleni
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Karakatsani, Ann ...
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Trichopoulou, An ...
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Pala, Valeria
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Masala, Giovana
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Panico, Salvator ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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May, Anne M.
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van Gils, Carla ...
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Rylander, Charlo ...
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Borch, Kristin B ...
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Chirlaque López, ...
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Sánchez, Maria J ...
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Ardanaz, Eva
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Quirós, José Ram ...
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Amiano Exezarret ...
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Sund, Malin
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Drake, Isabel
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Regnér, Sara
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Travis, Ruth C.
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Wareham, Nick
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Aune, Dagfinn
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Riboli, Elio
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Gunter, Marc J.
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Duell, Eric J.
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Brennan, Paul
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Ferrari, Pietro
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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European Journal ...
- By the university
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Lund University
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Umeå University