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  • Naudin, SabineInternational Agency for Research on Cancer, World Health Organization (author)

Healthy lifestyle and the risk of pancreatic cancer in the EPIC study

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2019-09-28
  • Springer Science and Business Media LLC,2020
  • 12 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:7f473c44-2c9b-4e11-8122-21d7e1a75c85
  • https://lup.lub.lu.se/record/7f473c44-2c9b-4e11-8122-21d7e1a75c85URI
  • https://doi.org/10.1007/s10654-019-00559-6DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176113URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) were diagnosed from 400,577 participants followed-up for 15 years (median). HLI scores combined smoking, alcohol intake, dietary exposure, physical activity and, in turn, overall and central adiposity using BMI (HLIBMI) and waist-to-hip ratio (WHR, HLIWHR), respectively. High values of HLI indicate adherence to healthy behaviors. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and 95% confidence intervals (CI). Sensitivity analyses were performed by excluding, in turn, each factor from the HLI score. Population attributable fractions (PAF) were estimated assuming participants’ shift to healthier lifestyles. The HRs for a one-standard deviation increment of HLIBMI and HLIWHR were 0.84 (95% CI: 0.79, 0.89; ptrend = 4.3e−09) and 0.77 (0.72, 0.82; ptrend = 1.7e−15), respectively. Exclusions of smoking from HLIWHR resulted in HRs of 0.88 (0.82, 0.94; ptrend = 4.9e−04). The overall PAF estimate was 19% (95% CI: 11%, 26%), and 14% (6%, 21%) when smoking was removed from the score. Adherence to a healthy lifestyle was inversely associated with PC risk, beyond the beneficial role of smoking avoidance. Public health measures targeting compliance with healthy lifestyles may have an impact on PC incidence.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Viallon, VivianInternational Agency for Research on Cancer, World Health Organization (author)
  • Hashim, DanaIcahn School of Medicine at Mount Sinai (author)
  • Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization (author)
  • Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization (author)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization (author)
  • Perrier, FlavieInternational Agency for Research on Cancer, World Health Organization (author)
  • McKenzie, FionaInternational Agency for Research on Cancer, World Health Organization (author)
  • Bueno-de-Mesquita, H. BasNational Institute for Public Health and the Environment (RIVM),Imperial College London,University Medical Center Utrecht (author)
  • Olsen, AnjaDanish Cancer Society (author)
  • Tjønneland, AnneUniversity of Copenhagen,Danish Cancer Society (author)
  • Dahm, Christina C.Aarhus University (author)
  • Overvad, KimAalborg University,Aarhus University (author)
  • Mancini, Francesca R.Institut Gustave Roussy (author)
  • Rebours, VincianeBeaujon Hospital,Paris Diderot University (author)
  • Boutron-Ruault, Marie ChristineInstitut Gustave Roussy (author)
  • Katzke, VerenaGerman Cancer Research Centre (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Bergmann, ManuelaGerman Institute of Human Nutrition (author)
  • Boeing, HeinerGerman Institute of Human Nutrition (author)
  • Peppa, EleniHellenic Health Foundation, Athens (author)
  • Karakatsani, AnnaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens (author)
  • Trichopoulou, AntoniaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens (author)
  • Pala, ValeriaIstituto Nazionale dei Tumori (author)
  • Masala, GiovanaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (author)
  • Panico, SalvatoreUniversity of Naples Federico II (author)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (author)
  • Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin (author)
  • May, Anne M.University Medical Center Utrecht (author)
  • van Gils, Carla H.University Medical Center Utrecht (author)
  • Rylander, CharlottaUiT The Arctic University of Norway, Tromsø (author)
  • Borch, Kristin BenjaminsenUiT The Arctic University of Norway, Tromsø (author)
  • Chirlaque López, María DoloresUniversity of Murcia (author)
  • Sánchez, Maria JoseUniversity of Granada (author)
  • Ardanaz, EvaHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP),Navarre Public Health Institute (ISPN)(Swepub:lu)extLU-05 (author)
  • Quirós, José RamónPublic Health Directorate (author)
  • Amiano Exezarreta, Pilar (author)
  • Sund, MalinUmeå universitet,Umeå University,Kirurgi(Swepub:umu)masu0021 (author)
  • Drake, IsabelLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-ihm (author)
  • Regnér, SaraLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)kir-sre (author)
  • Travis, Ruth C.University of Oxford (author)
  • Wareham, NickUniversity of Cambridge (author)
  • Aune, DagfinnOslo university hospital,Bjørknes University College,Imperial College London (author)
  • Riboli, ElioImperial College London (author)
  • Gunter, Marc J.International Agency for Research on Cancer, World Health Organization (author)
  • Duell, Eric J.Catalan Institute of Oncology (author)
  • Brennan, PaulInternational Agency for Research on Cancer, World Health Organization (author)
  • Ferrari, PietroInternational Agency for Research on Cancer, World Health Organization (author)
  • International Agency for Research on Cancer, World Health OrganizationIcahn School of Medicine at Mount Sinai (creator_code:org_t)

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  • In:European Journal of Epidemiology: Springer Science and Business Media LLC35:10, s. 975-9860393-29901573-7284

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