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Dissection of proge...
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis
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- Jensen, Christina T (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Sweden
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- Åhsberg, Josefine (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Sweden
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- Sommarin, Mikael N E (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Sweden
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- Strid, Tobias (author)
- Linköpings universitet,Linköping University,Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Avdelningen för mikrobiologi och molekylär medicin,Lund Univ, Sweden
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- Somasundaram, Rajesh (author)
- Linköpings universitet,Linköping University,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Okuyama, Kazuki (author)
- Linköpings universitet,Linköping University,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Ungerbäck, Jonas (author)
- Linköpings universitet,Linköping University,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Kupari, Jussi (author)
- University of Helsinki,Univ Helsinki, Finland
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- Airaksinen, Matti S (author)
- University of Helsinki,Univ Helsinki, Finland,Lund Univ, Sweden
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- Lang, Stefan (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Sweden
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- Bryder, David (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Sweden
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- Soneji, Shamit (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine
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- Karlsson, Göran (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cells and Leukemia,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Lund Univ, Sweden
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- Sigvardsson, Mikael (author)
- Linköpings universitet,Linköping University,Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Avdelningen för mikrobiologi och molekylär medicin,Lund Univ, Sweden
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(creator_code:org_t)
- 2018-06-13
- 2018
- English 17 s.
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In: Journal of Experimental Medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 215:7, s. 1947-1963
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Abstract
Subject headings
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- To understand the developmental trajectories in early lymphocyte differentiation, we identified differentially expressed surface markers on lineage-negative lymphoid progenitors (LPs). Single-cell polymerase chain reaction experiments allowed us to link surface marker expression to that of lineage-associated transcription factors (TFs) and identify GFRA2 and BST1 as markers of early B cells. Functional analyses in vitro and in vivo as well as single-cell gene expression analyses supported that surface expression of these proteins defined distinct subpopulations that include cells from both the classical common LPs (CLPs) and Fraction A compartments. The formation of the GFRA2-expressing stages of development depended on the TF EBF1, critical both for the activation of stage-specific target genes and modulation of the epigenetic landscape. Our data show that consecutive expression of Ly6D, GFRA2, and BST1 defines a developmental trajectory linking the CLP to the CD19+ progenitor compartment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Jensen, Christin ...
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Åhsberg, Josefin ...
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Sommarin, Mikael ...
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Strid, Tobias
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Somasundaram, Ra ...
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Okuyama, Kazuki
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show more...
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Ungerbäck, Jonas
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Kupari, Jussi
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Airaksinen, Matt ...
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Lang, Stefan
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Bryder, David
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Soneji, Shamit
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Karlsson, Göran
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Sigvardsson, Mik ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Journal of Exper ...
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Lund University
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Linköping University