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Research Progress o...
Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases
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- Rolandsson Enes, Sara (author)
- Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups
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- Krasnodembskaya, Anna D. (author)
- Queen's University Belfast
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- English, Karen (author)
- Maynooth University
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- Dos Santos, Claudia C. (author)
- Saint Michael's Hospital
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- Weiss, Daniel J. (author)
- University of Vermont
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(creator_code:org_t)
- 2021-04-19
- 2021
- English.
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In: Frontiers in Pharmacology. - : Frontiers Media SA. - 1663-9812. ; 12
- Related links:
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Recent advances in cell based therapies for lung diseases and critical illnesses offer significant promise. Despite encouraging preclinical results, the translation of efficacy to the clinical settings have not been successful. One of the possible reasons for this is the lack of understanding of the complex interaction between mesenchymal stromal cells (MSCs) and the host environment. Other challenges for MSC cell therapies include cell sources, dosing, disease target, donor variability, and cell product manufacturing. Here we provide an overview on advances and current issues with a focus on MSC-based cell therapies for inflammatory acute respiratory distress syndrome varieties and other inflammatory lung diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- cell therapy
- lung diseases
- mesenchymal stromal cells (MSCs)
- mscs
- respiratory diseases and disorders
Publication and Content Type
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- ref (subject category)
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