Search: onr:"swepub:oai:lup.lub.lu.se:807b160f-c7f7-4b5b-8312-daed6102d9f8" >
Prediagnostic alter...
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Stepien, MagdalenaInternational Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
(author)
Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-01-11
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Wiley,2022
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14 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:807b160f-c7f7-4b5b-8312-daed6102d9f8
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https://lup.lub.lu.se/record/807b160f-c7f7-4b5b-8312-daed6102d9f8URI
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https://doi.org/10.1002/ijc.33885DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191669URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Bile acids (BAs) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved in various metabolic, inflammatory and immune-related processes. The liver is the primary site of BA synthesis. Liver dysfunction and microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate BA metabolism increasing concentration of carcinogenic BAs. Observations from prospective cohorts are sparse. We conducted a study (233 HCC case-control pairs) nested within a large observational prospective cohort with blood samples taken at recruitment when healthy with follow-up over time for later cancer development. A targeted metabolomics method was used to quantify 17 BAs (primary/secondary/tertiary; conjugated/unconjugated) in prediagnostic plasma. Odd ratios (OR) for HCC risk associations were calculated by multivariable conditional logistic regression models. Positive HCC risk associations were observed for the molar sum of all BAs (ORdoubling = 2.30, 95% confidence intervals [CI]: 1.76-3.00), and choline- and taurine-conjugated BAs. Relative concentrations of BAs showed positive HCC risk associations for glycoholic acid and most taurine-conjugated BAs. We observe an association between increased HCC risk and higher levels of major circulating BAs, from several years prior to tumor diagnosis and after multivariable adjustment for confounders and liver functionality. Increase in BA concentration is accompanied by a shift in BA profile toward higher proportions of taurine-conjugated BAs, indicating early alterations of BA metabolism with HCC development. Future studies are needed to assess BA profiles for improved stratification of patients at high HCC risk and to determine whether supplementation with certain BAs may ameliorate liver dysfunction.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Lopez-Nogueroles, MarinaCIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Analytical Unit, Health Research Institute Hospital La Fe, Valencia, Spain
(author)
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Lahoz, AgustinCIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Analytical Unit, Health Research Institute Hospital La Fe, Valencia, Spain
(author)
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Kühn, TilmanDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
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Perlemuter, GabrielInflammation, Chimiokines et Immunopathologie (Inserm Umr 996),INSERM U996, Intestinal Microbiota, Macrophages and Liver Inflammation, DHU Hepatinov, Labex LERMIT, Clamart, France; Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France,University of Paris-Saclay
(author)
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Voican, CosminINSERM U996, Intestinal Microbiota, Macrophages and Liver Inflammation, DHU Hepatinov, Labex LERMIT, Clamart, France; Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France,Antoine-Béclère Hospital,Inflammation, Chimiokines et Immunopathologie (Inserm Umr 996)
(author)
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Ciocan, DragosInflammation, Chimiokines et Immunopathologie (Inserm Umr 996),INSERM U996, Intestinal Microbiota, Macrophages and Liver Inflammation, DHU Hepatinov, Labex LERMIT, Clamart, France; Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France,University of Paris-Saclay
(author)
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Boutron-Ruault, Marie ChristineVersailles Saint-Quentin-en-Yvelines University,Institut Gustave Roussy,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
(author)
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Jansen, EugeneNational Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
(author)
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Viallon, VivianInternational Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
(author)
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Leitzmann, MichaelDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany
(author)
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Tjønneland, AnneDiet, Genes and Environment Unit, Danish Cancer Society Research Center, Copenhagen, Denmark
(author)
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Severi, GianlucaInstitut Gustave Roussy,Versailles Saint-Quentin-en-Yvelines University,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
(author)
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Mancini, Francesca RomanaVersailles Saint-Quentin-en-Yvelines University,Institut Gustave Roussy,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
(author)
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Dong, CatherineVersailles Saint-Quentin-en-Yvelines University,Institut Gustave Roussy,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France; Department of Gastroenterology, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France
(author)
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Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
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Fortner, Renee TurzanskiDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
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Bergmann, Manuela M.Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
(author)
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Boeing, HeinerDepartment of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
(author)
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Trichopoulou, AntoniaHellenic Health Foundation, Athens, Greece
(author)
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Karakatsani, AnnaHellenic Health Foundation, Athens, Greece; 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, “ATTIKON” University Hospital, Haidari, Greece,National and Kapodistrian University of Athens
(author)
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Peppa, EleniHellenic Health Foundation, Athens, Greece
(author)
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Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network—ISPRO, Florence, Italy
(author)
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Krogh, VittorioEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Milano, Milan, Italy
(author)
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Tumino, RosarioCivic and M.P Arezzo Hospital,Department of Cancer Registry and Histopathology, “M.P. Arezzo” Hospital, ASP Ragusa, Ragusa, Italy
(author)
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Sacerdote, CarlottaUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy
(author)
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Panico, SalvatoreDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
(author)
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Bueno-de-Mesquita, H. BasDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands; Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom; Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia,University Medical Center Utrecht,University of Malaya,Imperial College London
(author)
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Skeie, GuriDepartment of Community Medicine, UIT—The Arctic University of Norway, Tromsø, Norway
(author)
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Merino, SusanaPublic Health Directorate, Asturias, Spain
(author)
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Ros, Raul ZamoraUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
(author)
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Sánchez, Maria JoseUniversity of Granada,CIBER Epidemiology and Public Health (CIBERESP),Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
(author)
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Amiano, PilarCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain,Biodonostia Health Research Institute
(author)
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Huerta, Jose MªCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP)
(author)
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Barricarte, AurelioCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain,CIBER Epidemiology and Public Health (CIBERESP)
(author)
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Sjöberg, KlasLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Department of Gastroenterology and Nutrition, Lund University, Skåne University Hospital, Malmö, Sweden(Swepub:lu)medf-ksj
(author)
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Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Department of Internal Medicine, Lund University, Skåne University Hospital, Malmö, Sweden(Swepub:lu)kir-boh
(author)
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Nyström, Hanna,1980-Umeå universitet,Umeå University,Kirurgi(Swepub:umu)haanym01
(author)
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Werner, MårtenUmeå universitet,Umeå University,Avdelningen för medicin(Swepub:umu)manwer04
(author)
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Perez-Cornago, AuroraCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
(author)
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Schmidt, Julie A.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
(author)
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Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
(author)
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Scalbert, AugustinInternational Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
(author)
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Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization,Office of the Director, International Agency for Research on Cancer (IARC-WHO), Lyon, France
(author)
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Christakoudi, SofiaDepartment of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; MRC Centre for Transplantation, King's College London, London, United Kingdom,King's College London
(author)
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Gunter, Marc J.International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
(author)
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Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
(author)
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International Agency for Research on Cancer, World Health OrganizationNutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
(creator_code:org_t)
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In:International Journal of Cancer: Wiley150:8, s. 1255-12680020-71361097-0215
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Kühn, Tilman
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Fortner, Renee T ...
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Bergmann, Manuel ...
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