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  • Pincikova, T.Karolinska Institutet (author)

Vitamin D deficiency as a risk factor for cystic fibrosis-related diabetes in the Scandinavian Cystic Fibrosis Nutritional Study

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-09-07
  • Springer Science and Business Media LLC,2011

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:8302de9a-1079-4608-93bb-3ab6b685698b
  • https://lup.lub.lu.se/record/2291919URI
  • https://doi.org/10.1007/s00125-011-2287-1DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-164837URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123669502URI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aims/hypothesis Many cystic fibrosis patients are vitamin D-insufficient. Cystic fibrosis-related diabetes is a major complication of cystic fibrosis. The literature suggests that vitamin D might possess certain glucose-lowering properties. We aimed to assess the relationship between vitamin D and cystic fibrosis-related glucose intolerance. Methods We enrolled 898 cystic fibrosis patients from Sweden, Norway and Denmark. Vitamin D intake was assessed using a seven-day food record. Serum 25-hydroxyvitamin D (s25OHD) and HbA(1c) were measured, and an OGTT was carried out. Multiple linear and logistic regressions were used for HbA(1c) and cystic fibrosis-related diabetes/OGTT result as outcome variables, respectively. Each model was controlled for country, and for known cystic fibrosis-related diabetes risk factors: age, sex, genotype, liver dysfunction, long-term corticosteroid treatment, and lung and pancreatic function. Results Degree of vitamin D insufficiency (OR 1.36; p=0.032) and s25OHD<30 nmol/l (OR 1.79; p=0.042) were significant risk factors for cystic fibrosis-related diabetes. Accordingly, HbA(1c) value was positively associated with s25OHD<30 nmol/l and<50 nmol/l, as well as with degree of vitamin D insufficiency (adjusted R-2=20.5% and p<0.05 in all). In subgroup analyses, s25OHD<30 nmol/l determined the HbA(1c) value in paediatric patients (adjusted R-2=20.2%; p=0.017), but not in adults. Conclusions/interpretation Vitamin D status is associated with HbA(1c) and diabetes in cystic fibrosis, particularly in children. The study justifies prospective studies on the proposed role of vitamin D deficiency in the pathophysiology of diabetes mellitus.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Nilsson, K.Stockholm CF Centre, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden (author)
  • Moen, I. E.National Centre for Cystic Fibrosis, University Hospital Ullevaal, Oslo, Norway (author)
  • Fluge, G.Cystic Fibrosis Centre, Department of Paediatrics, Haukeland University Hospital, Bergen, Norway (author)
  • Hollsing, Annika,1949-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall(Swepub:uu)annho840 (author)
  • Knudsen, P. K.National Centre for Cystic Fibrosis, University Hospital Ullevaal, Oslo, Norway (author)
  • Lindblad, A.The West Swedish CF Centre, Sahlgrenska University Hospital, Gothenburg, Sweden (author)
  • Mared, LenaLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung Centre, Lund University Hospital, Lund, Sweden(Swepub:lu)lung-lma (author)
  • Pressler, T.Cystic Fibrosis Centre, Department of Paediatrics, Copenhagen University Hospital, Denmark (author)
  • Hjelte, L.Karolinska Institutet (author)
  • Karolinska InstitutetStockholm CF Centre, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer Science and Business Media LLC54:12, s. 3007-30151432-04280012-186X

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