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Twins studies as a model for studies on the interaction between smoking and genetic factors in the development of chronic bronchitis
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- Svartengren, Magnus (author)
- Karolinska Institutet
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Anderson, Martin (author)
- Karolinska Institutet
- show more...
- Edula, Goutham (author)
- de Verdier, Maria Gerhardsson (author)
- Dahlback, Magnus (author)
- Lindberg, Claes M. (author)
- Forsman-Semb, Kristina (author)
- Fehniger, Thomas E. (author)
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- (creator_code:org_t)
- 2009
- 2009
- English.
- In: Biochemical Society Transactions. - 1470-8752 .- 0300-5127. ; 37, s. 814-818
- Conference paper (peer-reviewed)
Abstract
Subject headings
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- Smoking is the main risk factor for COPD (chronic obstructive pulmonary disease) but genetic factors are of importance, since only a subset of smokers develops the disease. Sex differences have been suggested both in disease prevalence and response to environmental exposures. Furthermore, it has been shown that acquisition of 'addiction' to smoking is partly genetically mediated. Disease cases and smoking habits were identified in 44919 twins aged > 40 years from the Swedish Twin Registry. Disease was defined as self-reported chronic bronchitis or emphysema, or recurrent cough with phlegm. The results showed that chronic bronchitis seems to be more prevalent among females, and that the heritability estimate for chronic bronchitis was a moderate 40% and only 14% of the genetic influences were shared by smoking. In addition, 392 twins have been invited to a clinical investigation to evaluate: (i) to what extent genetic factors contribute to individual differences (variation) in FEV1 (forced expiratory volume in 1 s), vital capacity and l (diffusion capacity), taking sex into consideration, and (ii) whether smoking behaviour and respiratory symptoms influence these estimates.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- inflammatory marker
- chronic obstructive pulmonary disease (COPD)
- heritability
- multi-slice computed tomography (MSCT)
- smoking
- twin
Publication and Content Type
- kon (subject category)
- ref (subject category)
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